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History/Changes made to Toxicity Criteria Database

Posted updated pdf of OEHHA cpfs
[01/25/08]

Added cancer potency information for ethylbenzene based on the adoption of a unit risk for ethylbenzene
[01/25/08]

Corrected CSFi for 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin to 13,000.
Corrected Inhalation Unit Risk value for 2,3',4,4'5,5'-hexachlorobiphenyl to 0.00038 (ug/m3) -1
Corrected Inhalation Unit Risk value for 3,3',4,4',5,5'-hexachlorobiphenyl to 0.38 (ug/m3) -1
All data input errors.
[07/10/07]

Slope factors for the following chemicals corrected. New pdf file of values added. (Data entry error) 1,2,3,4,6,7,8-Heptachlorodibenzofuran, 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin, 1,2,3,4,7,8,9-Heptachlorodibenzofuran, 1,2,3,4,7,8-Hexachlorodibenzofuran, 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin, 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin, 1,2,3,7,8,9-Hexachlorodibenzofuran, 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin, 1,2,3,7,8-Pentachlorodibenzofuran, 2,3,3',4,4',5'-HxCB, 2,3,3',4,4',5-HxCB, 2,3',4,4',5,5'-HxCB,
2,3,4,4',5-PeCB, 2,3,4,6,7,8-Hexachlorodibenzofuran, 3,3',4,4',5,5'-HxCB (thanks Jon!)
[06/12/07]

Corrected CAS number for 2,3,4,7,8,9-Hexachlorodibenzofuran. The corrected CAS number is 57117449. Updated PDF lists with corrected CAS number. (thanks Jon!)
[04/24/07]

Listed potency factors for the chemicals 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin and 2,3,4,6,7,8-Hexachlorodibenzofuran. Both chemicals use Hot Spots TEFs.

Removed information for 1,2,3,6,7,-HxCDF, 2,3,4,6,7,8-HxCDD and 2,3,4,7,8,9-Hexachlorodibenzofuran.

Posted new pdf of updated OEHHA CPFs
[04/09/07]

Oral Slope factor for Cadmium removed from database. Previous number was based on a PHG that was updated. Current cadmium PHG does not use cancer as the endpoint.
[04/03/07]

DHS MCL for trichloroethene changed from 0.00008 mg/l to 0.005 mg/l to reflect change by DHS (documentation can be found here)
[01/17/07]

Public Health Goal (PHG) for cadmium changed from 0.07ppb to 0.04 ppb to reflect updated PHG
[12/22/06]

Public Health Goal (PHG) for perchlorate changed from 6mg to 0.006mg. Data input error.
[12/05/06]

CAS number for Methyl Ethyl Ketone corrected (78-93-3)
[09/21/06]

Cancer potency information for naphthalene readded to the data base. Data input error
[03/21/06]

PHG information for the chemicals: cis/trans-1,2-Dichloroethylene, 1,1,1-Trichloroethane, 1,1,2-Trichloroethane, Radium-226 and –228, Strontium-90, and Tritium added.
[03/21/06]

Proposition 65 MADL for Methyl Mercury withdrawn. Value obsolete.
[09/19/05]

IARC and IRIS classifications added for 38 chemicals. PDF files for the database updated
[08/10/05]

Unit Risk value (3.4E-5) and slope factor (1.2E-1) added for naphthalene. Unit risk adopted by OEHHA
[06/09/05]

Entry for perchlorate changed from 6.0 mg/L to 00.6 mg/L. Data entry error.
[03/17/05]

California MCL for the chemical Trichloroethylene (CAS 79016) updated from 0.0008 to 0.005
[09/29/04]

Corrected oral slope factors for 1,2,3,7,8-Pentachlorodibenzofuran, 1,2,3,4,6,7,8-Heptachlorodibenzofuran, 1,2,3,4,7,8,9-Heptachlorodibenzofuran, 1,2,3,4,7,8-Hexachlorodibenzofuran, 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin, 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin, 1,2,3,7,8,9-Hexachlorodibenzofuran, 1,2,3,7,8-Pentachlorodibenzofuran.

Replaced pdf files with corrected values.
[09/24/04]

Added cancer potency data for previously omitted TEF's: 1,2,3,7,8,9-HxCDD, 1,2,3,6,7,7-HxCDF, 2,3,4,6,7,8-HxCDD
[09/22/04]

Added Chronic REL data for Carbon disulfide, 1,4-dichlorobenzene, 1,4-dioxane, 1,2 epoxybutane, n-hexane, 4,4-methylene dianiline and phosphine
[09/22/04]

Updated values for Proposition 65 NSRL's/MADL's added to database. Reference changed to June 2004 Proposition 65 Status report.
[09/22/04]

Oral unit risks and slope factors added for the following chemicals: 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 3,3',4,4'-TCB, 3,4,4',5-TCB, 2,3,3',4,4'-PeCB, 2,3,4,4',5-PeCB, 2,3',4,4',5-PeCB, 2',3,4,4',5-PeCB, 3,3',4,4',5-PeCB, 2,3,3',4,4',5-HxCB, 2,3,3',4,4',5'-HxCB, 2,3',4,4',5,5'-HxCB, 3,3',4,4',5,5'-HxCB, 2,3,3',4,4',5,5'-HpCB. All use the reference: OEHHA, 2003 Adoption of the Revised Toxicity Equivalency Factors (TEF WHO-97) for PCDDs, PCDFs, and Dioxin-Like PCBs
[06/03/04]

No Significant Risk Levels (NSRLs) added or changed for the following proposition 65 chemicals: Benzofuran, Bromoform, N-Carboxymethyl-N-nitrosourea, Chloroethane, p-Chloro-o-toluidine hydrochloride, Di(2-ethylhexyl)phthalate, 3,3'-Dimethoxybenzidine, 3,3'-Dimethoxybenzidine dihydrochloride, 3,3'-Dimethylbenzidine, 3,3'-Dimethylbenzidine dihydrochloride, Isobutyl nitrite, Lead, Lead acetate, Lead phosphate, Lead subacetate, Propyleneimine, Methylhydrazine, Methylhydrazine sulfate, MeIQ (2-Amino-3,4-dimethyl-imidazo[4,5-f]quinoline), MeIQx (2-Amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline), 5-Morpholinomethyl-3-[(5-nitro-furfurylidene)-amino]-2-oxazolidinone, MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2-(5H)-furanone), Nalidixic acid, o-Phenylenediamine, o-Phenylenediamine dihydrochloride, Phenylhydrazine, Phenylhydrazine hydrochloride, Polygeenan, Methyl carbamate, 4-(N-Nitrosomethylamino)-1- (3-pyridyl)-1-butanone, Tetranitromethane, Trimethyl phosphate, 2,6-Xylidine
Reference: http://www.oehha.ca.gov/prop65/pdf/Sept2003StatusReport.pdf
[05/25/04]

Inhalation slope factor for 1,2,3,7,8-PeCDD updated from 65,000 to 130,000 and oral slope factor added. Inhalation slope factor for 1,2,3,4,6,7,8,9-OCDD updated from 130 to 13 and oral slope factor added. Inhalation slope factor for 1,2,3,4,6,7,8,9-OCDF updated from 130 to 13 and oral slope factor added. All reflect new reference of OEHHA 2003 Adoption of the Revised Toxicity Equivalency Factors (TEF WHO-97) for PCDDs, PCDFs, and Dioxin-Like PCBs
[05/21/04]

Proposition 65 NSRLs for benzene changed from 7 (oral) to 6.4 (oral) and 13 (inh). NSRL of 64 added for bromoform.
[05/04/04]

Information for new PHG (April 23, 2004): arsenic added to database. Slope factor: 9.45 mg/kg-day.
[04/27/04]

Information for new PHG (March 12, 2004): perchlorate added to database
[03/17/04]

Information for new PHGs (Nov. 26, 2003): asbestos, barium, beryllium, chlorobenzene, 1,1-dichloroethane, diethylhexyl adipate, ethylene dibromide, hexachlorobenzene, silvex, 1,1,2,2-tetrachloroethane, and toxaphene added to database
[12/12/03]

MADLs for the Proposition 65 chemicals: 2,4-D butyric acid (94826), Hydramethylnon (67485294), Linuron (330552), N-Methylpyrrolidone (872504), Quizalofop-ethyl (76578148) added to reflect current Proposition 65 Status report
[10/25/03]

Oral slope factor for trichloroethylene (TCE) change from 0.0153 (mg/kg-day)-1 to 0.013 (mg/kg-day)-1. Data input error.
[09/24/03]

Chronic REL for Flourides added.
[08/17/03]

NSRL for Toluene removed from database (data input error). Inhalation MADL of 13,000 ug/day for toluene added to database.
[08/17/03]

PHG for Tetrachloroethylene (CAS Number 127184) changed from 0.06 mg/L to 0.06 ug/L. Data input error.
[03/04/03]

Inhalation cancer potency slope for MTBE changed from 1.8 E-3 to 9.1E-4 to correct data input error.
[12/23/02]

Inhalation slope factor of 2.2 E+2 for Asbestos added.
Unit risk/cancer potency factors for N-Nitroso-N-methylamine changed from 3.7 E+0 to 2.2 E+1
Trichloroethylene unit risk/cancer potency changed from 1.0E-2 to 7.0 E-3
All changes the result of correction to the Technical Support Document for Cancer POtency Factors.
[12/20/02]

Chronic REL for acetaldehyde changed from 200 mg/m3 to 9 mg/m3 to correct data input error.
[10/09/02]

Inhalation unit risk factor for tetrachloroethylene
changed from 5.6 x 10-5 to 5.9 x 10-6. Inhalation reference to remain 1999 Technical Support document.
[9/13/02]

PDF file of cancer potency factors updated to reflect change to tetrachloroethylene
[09/11/02]

Inhalation unit risk for tetrachloroethylene (CAS# 127-18-4) changed from 5.9 x E-6 to 5.6 x 10-5; and oral and inhalation slope factors changed from 0.051 and 0.021(mg/kg-d)-1 to 0.54 and 0.15 (mg/kg-d)-1 to account for new data. The former numbers were based on the 1999 Technical Support Document for Describing Available Cancer Potency Factors. The newer numbers are based on the 1999 Public Health Goal for Tetrachloroethylene.
[07/16/02]

California MCL for perchlorate removed. There is currently no MCL for perchlorate.
[06/06/02]

Cancer Slope Factor and Inhalation Unit Risk changed for 1, 2 Dichloroethane (CAS 107-06-2) from 7.0 E-2 and 2.2E-5 to 7.2E-2 and 2.1E-5 to correct calculation error.
[05/01/02]

Inhalation unit risk value for 1,2 Dichloropropane corrected from 1.8E-5 to 1.0 E-5 to correct calculation error.
[04/30/02]

Reference added to the listing for 1,2 Dichloroethane
[04/30/02]

Values for 50 Chronic RELs added to the database.
[02/08/02]

Acute REL for Sulfur dioxide (660ug/m3) added.
[02/07/02]

Oral potency of 0.19 (mg/kg/day)-1 for Chromium VI withdrawn.
[12/19/01]

Change made to the California MCL for perchlorate. Units changed from 0.0018 mg/L, to 0.018 mg/L, to reflect data input error.
[09/18/01]

Reference added to document PCB oral value - CDHS 1988.
[08/27/01]

Change made to the slope factor for 2,3,7,8 Hexachlorobenzo-p-dioxin (mixture) from 1.3E5 to 1.3E4, to correct a calculation error.
[05/07/01]

PDF file updated to reflect changes made.
[03/07/01]

Change made to the inhalation unit risk value for 1-nitropyrene from 1.0E-4 to 1.1E-4. The original number was the result of a data input error.
[03/07/01]

Changes made to the CAS numbers of aniline and chromium VI. Incorrect CAS numbers were previously entered.
[03/07/01]

Change made to the unit risk for Tetrachloroethylene from 5.6E-6 to 5.9E-6. The original number was the result of a data input error.
[12/14/00]

Change made to inhalation slope factor for 2,3,7,8-Hexachlorodibenzo-p-dioxin (mixture) from 3.3E+3 to 1.3E+5 to reflect documentation provided by ATES.
[12/14/00]

Change made to the inhalation slope factor for 1,1,2 Trichloroethane from 17 to 0.057. The unit value listed in the supporting documentation was found to be incorrect.
[12/13/00]

Changes to listed unit values for: carbofuran, carbon tetrachloride, dichloromethane, heptachlor, heptachlor epoxide, thiobencarb.
Units had been incorrectly listed in ug/L/day.
[10/20/00]

 
 
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