A meeting of the Proposition 651 Carcinogen Identification Committee (CIC) was held on October 12, 2011, at the California Environmental Protection Agency Headquarters Building in Sacramento, California. The Committee considered the listing of Tris(1,3-dichloro-2-propyl) phosphate and fluoride and its salts as known to the state cause cancer. The Committee also provided OEHHA with its advice concerning the relative priority of 39 chemicals for possible hazard identification material preparation. In addition, the Committee discussed procedures for public comment presentations, committee discussions and committee voting. Following is a summary of that meeting.
SUMMARY OF THE LISTING DECISION FOR TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE (TDCPP) AND FLUORIDE AND ITS SALTS
Following a staff presentation, comments from the public and committee discussion, the CIC determined on a 5-1 vote that TDCPP has been clearly shown to cause cancer. The CIC determined on a 6-0 vote that fluoride and its salts has not been clearly shown to cause cancer.
Follow these links to the slide presentations made at the meeting by staff of the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) and members of the public:
TDCPP staff presentation and supplemental slides, John Faust, Ph.D. and Laura August, M.P.H., OEHHA
TDCPP public presentations, Nancy O’Malley, D.V.M., Ph.D. Albemarle Corporation and Andy Wang, Ph.D., ICL-IP America Inc.
Fluoride and its salts staff presentation, David Morry, Ph.D. and Craig Steinmaus, M.D., M.P.H., OEHHA
Fluoride and its salts public presentation, Howard Pollick, B.D.S., M.P.H, California Dental Association Foundation
SUMMARY OF CHEMICAL PRIORITIZATION DISCUSSION
The CIC recommended that 7 of the 39 chemicals referred to them for advice and consultation be placed in the ‘high’ priority group, 21 chemicals be placed in the ‘medium’ priority group, and the remaining 11 be placed in the ‘low’ priority group (see table below for specific suggestions concerning chemical priority assignments.) Follow this link to the slide presentation made by OEHHA. For more information on the prioritization process for chemicals, please click here.
High |
Medium |
Low |
Acetominophen |
Abacavir and its salts |
Chloropicrin |
Butyl benzyl phthalate |
Bisphenol A |
Dicloran |
C.I. Disperse Yellow 3 |
Butylated hydroxytoluene |
Hexythiazox |
Coumarin |
Chloroalkyl ethers |
Hydrazine and its salts |
Dibenzanthracenes and Dibenz[a,c]anthracene |
Clodinafop-propargyl |
Isophosphamide |
2,4-Dichlorophenoxyacetic acid and its salts and esters |
Dapsone |
Metofluthrin |
N-Methyl-N-nitroso-1-alkylamines and N-methyl-N-nitroso-1-octanamine and N-methyl-N-nitroso-1-decanamine and N-methyl-N-nitroso-1-dodecanamine and N methyl-N-nitroso-1-tetradecanamine |
3,3'-Dichlorobenzidine-based compounds metabolized to 3,3'-dichlorobenzidine |
N-Methylpyrrolidone |
|
Dinitroaniline pesticides* (prodiamine and trifluralin) |
6-Nitrobenzimidazole |
|
Entecavir |
Pentachloronitrobenzene |
|
Flonicamid |
Pivalolactone |
|
Fluazinam |
Pyraflufen ethyl |
| Mixtures containing pentabromochlorocyclohexane | ||
| N-Nitroso-N-methylaniline | ||
| Pimecrolimus | ||
| Raloxifen and its salts | ||
| Stavudine | ||
| Thiophanate methyl | ||
| Topoisomerase II Inhibitors | ||
| Triazole antifungal agents | ||
| 2,4,6-Trimethylaniline and its salts | ||
|
Tris(2-ethylhexyl) phosphate |
|
SUMMARY OF THE COMMITTEE MEETING PROCEDURES DISCUSSION
Following the staff presentation and committee discussion, the CIC advised that they generally prefer the following guidelines:
