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A meeting of the Developmental and Reproductive Toxicant (DART) Identification Committee was held on December 4, 2002, at the Employment Development Department, Auditorium in Sacramento, California. Below are the presentations made by staff of California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA). The segments of the agenda covered by this material include the "Consideration of a Chemical Known to the State to Cause Reproductive Toxicity," "Consideration of Chemicals, Listed Via the Authoritative Bodies Mechanism, For Removal From the List," "Consideration of Designation of the Center for Evaluation of Risks to Human Reproduction as an Authoritative Body," and "Consideration of Requests for Expedited Review for Subsequent Listing of Perchlorate and 1-Bromopropane."

The DART Identification Committee determined that diuron had not been clearly shown to cause reproductive toxicity; therefore, diuron is not added to the Proposition 65 chemical list. The Committee determined that bromacil lithium salt should remain on the Proposition 65 chemical list as known to the state to cause reproductive toxicity, specifically for the endpoint of developmental toxicity for which it is already listed and in addition, for male reproductive toxicity. Several supplementary slides were presented to clarify issues raised by commenters and are denoted with an * below. The DART Identification Committee also designated the National Toxicology Program (NTP) as an authoritative body solely as to final documents released by the NTP's Center for Evaluation of Risks to Human Reproduction. As to the consideration of the expedited review of perchlorate and 1-bromopropane for subsequent listing, the Committee asked OEHHA to take perchlorate out of the usual prioritization process order and to prepare a draft hazard identification document (HID) as resources are available. In addition, the Committee asked for a written progress report in six months on the status of development of the HID and other regulatory actions involving perchlorate. The Committee found no basis for expediting the review of 1-bromopropane. Therefore, 1-bromopropane will follow the usual prioritization process as described in the May 1997 document, "The Procedure For Prioritizing Candidate Chemicals For Consideration Under Proposition 65 By The 'State's Qualified Experts.'"

Meeting Agenda

Consideration of Chemicals Known to the State to Cause Reproductive Toxicity
Diuron (and *Structures of Related Compounds Slide)
Poorni Iyer, D.V.M., Ph.D., OEHHA

Consideration of Chemicals, Listed Via the Authoritative Bodies Mechanism, For Removal From the List
Bromacil Lithium Salt (and *Dose Conversion Slide)
Jim Morgan, Ph.D., OEHHA
*Maternal Stress and Fetal Supernumerary Ribs
Mari Golub, Ph.D., OEHHA

Consideration of Designation of the Center for Evaluation of Risks to Human Reproduction as an Authoritative Body
Jim Donald, Ph.D., OEHHA

Consideration of Requests for Expedited Review for Subsequent Listing
Perchlorate
Jim Donald, Ph.D., OEHHA
1-Bromopropane
Jim Donald, Ph.D., OEHHA

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