STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY JUNE 2, 2000 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout are chemicals recommended for removal from the list by the “state’s qualified experts.” CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER Chemical CAS Number Date A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) 26148685 January 1, 1990 Acetaldehyde 75070 April 1, 1988 Acetamide 60355 January 1, 1990 Acetochlor 34256821 January 1, 1989 2-Acetylaminofluorene 53963 July 1, 1987 Acifluorfen 62476599 January 1, 1990 Acrylamide 79061 January 1, 1990 Acrylonitrile 107131 July 1, 1987 Actinomycin D 50760 October 1, 1989 Adriamycin (Doxorubicin hydrochloride) 23214928 July 1, 1987 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide 3688537 July 1, 1987 Aflatoxins --- January 1, 1988 Alachlor 15972608 January 1, 1989 Alcoholic beverages, when associated with alcohol abuse --- July 1, 1988 Aldrin 309002 July 1, 1988 Allyl chloride Delisted October 29, 1999 107051 January 1, 1990 2-Aminoanthraquinone 117793 October 1, 1989 p-Aminoazobenzene 60093 January 1, 1990 ortho-Aminoazotoluene 97563 July 1, 1987 4-Aminobiphenyl (4-aminodiphenyl) 92671 February 27, 1987 1-Amino-2,4-dibromoanthraquinone 81492 August 26, 1997 3-Amino-9-ethylcarbazole hydrochloride 6109973 July 1, 1989 2-Aminofluorene 153786 January 29, 1999 1-Amino-2-methylanthraquinone 82280 October 1, 1989 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 712685 July 1, 1987 4-Amino-2-nitrophenol 119346 January 29, 1999 Amitrole 61825 July 1, 1987 Analgesic mixtures containing phenacetin --- February 27, 1987 Aniline 62533 January 1, 1990 Aniline hydrochloride 142041 May 15, 1998 ortho-Anisidine 90040 July 1, 1987 ortho-Anisidine hydrochloride 134292 July 1, 1987 Antimony oxide (Antimony trioxide) 1309644 October 1, 1990 Aramite 140578 July 1, 1987 Arsenic (inorganic arsenic compounds) --- February 27, 1987 Asbestos 1332214 February 27, 1987 Auramine 492808 July 1, 1987 Azacitidine 320672 January 1, 1992 Azaserine 115026 July 1, 1987 Azathioprine 446866 February 27, 1987 Azobenzene 103333 January 1, 1990 Benz[a]anthracene 56553 July 1, 1987 Benzene 71432 February 27, 1987 Benzidine [and its salts] 92875 February 27, 1987 Benzidine-based dyes --- October 1, 1992 Benzo[b]fluoranthene 205992 July 1, 1987 Benzo[j]fluoranthene 205823 July 1, 1987 Benzo[k]fluoranthene 207089 July 1, 1987 Benzofuran 271896 October 1, 1990 Benzo[a]pyrene 50328 July 1, 1987 Benzotrichloride 98077 July 1, 1987 Benzyl chloride 100447 January 1, 1990 Benzyl violet 4B 1694093 July 1, 1987 Beryllium and beryllium compounds --- October 1, 1987 Betel quid with tobacco --- January 1, 1990 2,2-Bis(bromomethyl)-1,3-propanediol 3296900 May 1, 1996 Bis(2-chloroethyl)ether 111444 April 1, 1988 N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) 494031 February 27, 1987 Bischloroethyl nitrosourea (BCNU) (Carmustine) 154938 July 1, 1987 Bis(chloromethyl)ether 542881 February 27, 1987 Bis(2-chloro-1-methylethyl)ether, technical grade --- October 29, 1999 Bitumens, extracts of steam-refined and air refined --- January 1, 1990 Bracken fern --- January 1, 1990 Bromodichloromethane 75274 January 1, 1990 Bromoform 75252 April 1, 1991 1,3-Butadiene 106990 April 1, 1988 1,4-Butanediol dimethanesulfonate (Busulfan) 55981 February 27, 1987 Butylated hydroxyanisole 25013165 January 1, 1990 beta-Butyrolactone 3068880 July 1, 1987 Cacodylic acid 75605 May 1, 1996 Cadmium and cadmium compounds --- October 1, 1987 Caffeic acid 331395 October 1, 1994 Captafol 2425061 October 1, 1988 Captan 133062 January 1, 1990 Carbazole 86748 May 1, 1996 Carbon tetrachloride 56235 October 1, 1987 Carbon-black extracts --- January 1, 1990 Ceramic fibers (airborne particles of respirable size) --- July 1, 1990 Certain combined chemotherapy for lymphomas --- February 27, 1987 Chlorambucil 305033 February 27, 1987 Chloramphenicol 56757 October 1, 1989 Chlordane 57749 July 1, 1988 Chlordecone (Kepone) 143500 January 1, 1988 Chlordimeform 6164983 January 1, 1989 Chlorendic acid 115286 July 1, 1989 Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) 108171262 July 1, 1989 p-Chloroaniline 106478 October 1, 1994 p-Chloroaniline hydrochloride 20265967 May 15, 1998 Chlorodibromomethane Delisted October 29, 1999 124481 January 1, 1990 Chloroethane (Ethyl chloride) 75003 July 1, 1990 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) 13010474 January 1, 1988 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea (Methyl-CCNU) 13909096 October 1, 1988 Chloroform 67663 October 1, 1987 Chloromethyl methyl ether (technical grade) 107302 February 27, 1987 3-Chloro-2-methylpropene 563473 July 1, 1989 1-Chloro-4-nitrobenzene 100005 October 29, 1999 4-Chloro-ortho-phenylenediamine 95830 January 1, 1988 p-Chloro-o-toluidine 95692 January 1, 1990 p-Chloro-o-toluidine, strong acid salts of --- May 15, 1998 5-Chloro-o-toluidine and its strong acid salts --- October 24, 1997 Chloroprene 126998 June 2, 2000 Chlorothalonil 1897456 January 1, 1989 Chlorotrianisene 569573 September 1, 1996 Chlorozotocin 54749905 January 1, 1992 Chromium (hexavalent compounds) --- February 27, 1987 Chrysene 218019 January 1, 1990 C.I. Acid Red 114 6459945 July 1, 1992 C.I. Basic Red 9 monohydrochloride 569619 July 1, 1989 C.I. Direct Blue 15 2429745 August 26, 1997 C.I. Direct Blue 218 28407376 August 26, 1997 C.I. Solvent Yellow 14 842079 May 15, 1998 Ciclosporin (Cyclosporin A; Cyclosporine) 59865133 79217600 January 1, 1992 Cidofovir 113852372 January 29, 1999 Cinnamyl anthranilate 87296 July 1, 1989 Cisplatin 15663271 October 1, 1988 Citrus Red No. 2 6358538 October 1, 1989 Clofibrate 637070 September 1, 1996 Cobalt metal powder 7440484 July 1, 1992 Cobalt [II] oxide 1307966 July 1, 1992 Cobalt sulfate heptahydrate 10026241 June 2, 2000 Coke oven emissions --- February 27, 1987 Conjugated estrogens --- February 27, 1987 Creosotes --- October 1, 1988 para-Cresidine 120718 January 1, 1988 Cupferron 135206 January 1, 1988 Cycasin 14901087 January 1, 1988 Cyclophosphamide (anhydrous) 50180 February 27, 1987 Cyclophosphamide (hydrated) 6055192 February 27, 1987 Cytembena 21739913 May 15, 1998 D&C Orange No. 17 3468631 July 1, 1990 D&C Red No. 8 2092560 October 1, 1990 D&C Red No. 9 5160021 July 1, 1990 D&C Red No. 19 81889 July 1, 1990 Dacarbazine 4342034 January 1, 1988 Daminozide 1596845 January 1, 1990 Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) 117102 January 1, 1992 Daunomycin 20830813 January 1, 1988 DDD (Dichlorodiphenyldichloroethane) 72548 January 1, 1989 DDE (Dichlorodiphenyldichloroethylene) 72559 January 1, 1989 DDT (Dichlorodiphenyltrichloroethane) 50293 October 1, 1987 DDVP (Dichlorvos) 62737 January 1, 1989 N,N'-Diacetylbenzidine 613354 October 1, 1989 2,4-Diaminoanisole 615054 October 1, 1990 2,4-Diaminoanisole sulfate 39156417 January 1, 1988 4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) 101804 January 1, 1988 2,4-Diaminotoluene 95807 January 1, 1988 Diaminotoluene (mixed) --- January 1, 1990 Dibenz[a,h]acridine 226368 January 1, 1988 Dibenz[a,j]acridine 224420 January 1, 1988 Dibenz[a,h]anthracene 53703 January 1, 1988 7H-Dibenzo[c,g]carbazole 194592 January 1, 1988 Dibenzo[a,e]pyrene 192654 January 1, 1988 Dibenzo[a,h]pyrene 189640 January 1, 1988 Dibenzo[a,i]pyrene 189559 January 1, 1988 Dibenzo[a,l]pyrene 191300 January 1, 1988 1,2-Dibromo-3-chloropropane (DBCP) 96128 July 1, 1987 2,3-Dibromo-1-propanol 96139 October 1, 1994 Dichloroacetic acid 79436 May 1, 1996 p-Dichlorobenzene 106467 January 1, 1989 3,3'-Dichlorobenzidine 91941 October 1, 1987 3,3?-Dichlorobenzidine dihydrochloride 612839 May 15, 1998 1,4-Dichloro-2-butene 764410 January 1, 1990 3,3'-Dichloro-4,4'-diaminodiphenyl ether 28434868 January 1, 1988 1,1-Dichloroethane 75343 January 1, 1990 Dichloromethane (Methylene chloride) 75092 April 1, 1988 1,2-Dichloropropane 78875 January 1, 1990 1,3-Dichloropropene 542756 January 1, 1989 Dieldrin 60571 July 1, 1988 Dienestrol 84173 January 1, 1990 Diepoxybutane 1464535 January 1, 1988 Diesel engine exhaust --- October 1, 1990 Di(2-ethylhexyl)phthalate 117817 January 1, 1988 1,2-Diethylhydrazine 1615801 January 1, 1988 Diethyl sulfate 64675 January 1, 1988 Diethylstilbestrol (DES) 56531 February 27, 1987 Diglycidyl resorcinol ether (DGRE) 101906 July 1, 1989 Dihydrosafrole 94586 January 1, 1988 Diisopropyl sulfate 2973106 April 1, 1993 3,3'-Dimethoxybenzidine (ortho-Dianisidine) 119904 January 1, 1988 3,3'-Dimethoxybenzidine dihydrochloride (ortho-Dianisidine dihydrochloride) 20325400 October 1, 1990 Dimethyl sulfate 77781 January 1, 1988 4-Dimethylaminoazobenzene 60117 January 1, 1988 trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- furyl)vinyl]-1,3,4- oxadiazole 55738540 January 1, 1988 7,12-Dimethylbenz(a)anthracene 57976 January 1, 1990 3,3'-Dimethylbenzidine (ortho-Tolidine) 119937 January 1, 1988 3,3'-Dimethylbenzidine dihydrochloride 612828 April 1, 1992 Dimethylcarbamoyl chloride 79447 January 1, 1988 1,1-Dimethylhydrazine (UDMH) 57147 October 1, 1989 1,2-Dimethylhydrazine 540738 January 1, 1988 Dimethylvinylchloride 513371 July 1, 1989 3,7-Dinitrofluoranthene 105735715 August 26, 1997 3,9-Dinitrofluoranthene 22506532 August 26, 1997 1,6-Dinitropyrene 42397648 October 1, 1990 1,8-Dinitropyrene 42397659 October 1, 1990 Dinitrotoluene mixture, 2,4-/2,6- --- May 1, 1996 2,4-Dinitrotoluene 121142 July 1, 1988 2,6-Dinitrotoluene 606202 July 1, 1995 Di-n-propyl isocinchomeronate (MGK Repellent 326) 136458 May 1, 1996 1,4-Dioxane 123911 January 1, 1988 Diphenylhydantoin (Phenytoin) 57410 January 1, 1988 Diphenylhydantoin (Phenytoin), sodium salt 630933 January 1, 1988 Direct Black 38 (technical grade) 1937377 January 1, 1988 Direct Blue 6 (technical grade) 2602462 January 1, 1988 Direct Brown 95 (technical grade) 16071866 October 1, 1988 Disperse Blue 1 2475458 October 1, 1990 Epichlorohydrin 106898 October 1, 1987 Erionite 12510428 October 1, 1988 Estradiol 17B 50282 January 1, 1988 Estragole 140670 October 29, 1999 Estrone 53167 January 1, 1988 Estropipate 7280377 August 26, 1997 Ethinylestradiol 57636 January 1, 1988 Ethyl acrylate 140885 July 1, 1989 Ethyl methanesulfonate 62500 January 1, 1988 Ethyl-4,4'-dichlorobenzilate 510156 January 1, 1990 Ethylene dibromide 106934 July 1, 1987 Ethylene dichloride (1,2-Dichloroethane) 107062 October 1, 1987 Ethylene oxide 75218 July 1, 1987 Ethylene thiourea 96457 January 1, 1988 Ethyleneimine 151564 January 1, 1988 Fenoxycarb 72490018 June 2, 2000 Folpet 133073 January 1, 1989 Formaldehyde (gas) 50000 January 1, 1988 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 3570750 January 1, 1988 Furan 110009 October 1, 1993 Furazolidone 67458 January 1, 1990 Furmecyclox 60568050 January 1, 1990 Fusarin C 79748815 July 1, 1995 Ganciclovir sodium 82410320 August 26, 1997 Gasoline engine exhaust (condensates/extracts) --- October 1, 1990 Glasswool fibers (airborne particles of respirable size) --- July 1, 1990 Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole) 67730114 January 1, 1990 Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) 67730103 January 1, 1990 Glycidaldehyde 765344 January 1, 1988 Glycidol 556525 July 1, 1990 Griseofulvin 126078 January 1, 1990 Gyromitrin (Acetaldehyde methylformylhydrazone) 16568028 January 1, 1988 HC Blue 1 2784943 July 1, 1989 Heptachlor 76448 July 1, 1988 Heptachlor epoxide 1024573 July 1, 1988 Hexachlorobenzene 118741 October 1, 1987 Hexachlorocyclohexane (technical grade) --- October 1, 1987 Hexachlorodibenzodioxin 34465468 April 1, 1988 Hexachloroethane 67721 July 1, 1990 Hexamethylphosphoramide 680319 January 1, 1988 Hydrazine 302012 January 1, 1988 Hydrazine sulfate 10034932 January 1, 1988 Hydrazobenzene (1,2-Diphenylhydrazine) 122667 January 1, 1988 Indeno [1,2,3-cd]pyrene 193395 January 1, 1988 IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) 76180966 April 1, 1990 Iprodione 36734197 May 1, 1996 Iron dextran complex 9004664 January 1, 1988 Isobutyl nitrite 542563 May 1, 1996 Isoprene 78795 May 1, 1996 Isosafrole 120581 October 1, 1989 Lactofen 77501634 January 1, 1989 Lasiocarpine 303344 April 1, 1988 Lead acetate 301042 January 1, 1988 Lead and lead compounds --- October 1, 1992 Lead phosphate 7446277 April 1, 1988 Lead subacetate 1335326 October 1, 1989 Lindane and other hexachlorocyclohexane isomers --- October 1, 1989 Mancozeb 8018017 January 1, 1990 Maneb 12427382 January 1, 1990 Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) 68006837 January 1, 1990 Medroxyprogesterone acetate 71589 January 1, 1990 MeIQ(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) 77094112 October 1, 1994 MeIQx(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) 77500040 October 1, 1994 Melphalan 148823 February 27, 1987 Merphalan 531760 April 1, 1988 Mestranol 72333 April 1, 1988 Metham sodium 137428 November 6, 1998 8-Methoxypsoralen with ultraviolet A therapy 298817 February 27, 1987 5-Methoxypsoralen with ultraviolet A therapy 484208 October 1, 1988 2-Methylaziridine (Propyleneimine) 75558 January 1, 1988 Methylazoxymethanol 590965 April 1, 1988 Methylazoxymethanol acetate 592621 April 1, 1988 Methyl carbamate 598550 May 15, 1998 3-Methylcholanthrene 56495 January 1, 1990 5-Methylchrysene 3697243 April 1, 1988 4,4'-Methylene bis(2-chloroaniline) 101144 July 1, 1987 4,4'-Methylene bis(N,N-dimethyl)benzenamine 101611 October 1, 1989 4,4'-Methylene bis(2-methylaniline) 838880 April 1, 1988 4,4'-Methylenedianiline 101779 January 1, 1988 4,4'-Methylenedianiline dihydrochloride 13552448 January 1, 1988 Methylhydrazine and its salts --- July 1, 1992 Methyl iodide 74884 April 1, 1988 Methylmercury compounds --- May 1, 1996 Methyl methanesulfonate 66273 April 1, 1988 2-Methyl-1-nitroanthraquinone (of uncertain purity) 129157 April 1, 1988 N-Methyl-N'-nitro-N-nitrosoguanidine 70257 April 1, 1988 N-Methylolacrylamide 924425 July 1, 1990 Methylthiouracil 56042 October 1, 1989 Metiram 9006422 January 1, 1990 Metronidazole 443481 January 1, 1988 Michler's ketone 90948 January 1, 1988 Mirex 2385855 January 1, 1988 Mitomycin C 50077 April 1, 1988 Monocrotaline 315220 April 1, 1988 5-(Morpholinomethyl)-3-[(5-nitro-furfurylidene)-amino]-2-oxazolidinone 139913 April 1, 1988 Mustard Gas 505602 February 27, 1987 Nafenopin 3771195 April 1, 1988 Nalidixic acid 389082 May 15, 1998 1-Naphthylamine 134327 October 1, 1989 2-Naphthylamine 91598 February 27, 1987 Nickel and certain nickel compounds --- October 1, 1989 Nickel carbonyl 13463393 October 1, 1987 Nickel refinery dust from the pyrometallurgical process --- October 1, 1987 Nickel subsulfide 12035722 October 1, 1987 Niridazole 61574 April 1, 1988 Nitrilotriacetic acid 139139 January 1, 1988 Nitrilotriacetic acid, trisodium salt monohydrate 18662538 April 1, 1989 5-Nitroacenaphthene 602879 April 1, 1988 5-Nitro-o-anisidine 99592 October 1, 1989 o-Nitroanisole 91236 October 1, 1992 Nitrobenzene 98953 August 26, 1997 4-Nitrobiphenyl 92933 April 1, 1988 6-Nitrochrysene 7496028 October 1, 1990 Nitrofen (technical grade) 1836755 January 1, 1988 2-Nitrofluorene 607578 October 1, 1990 Nitrofurazone 59870 January 1, 1990 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 555840 April 1, 1988 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 531828 April 1, 1988 Nitrogen mustard (Mechlorethamine) 51752 January 1, 1988 Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) 55867 April 1, 1988 Nitrogen mustard N-oxide 126852 April 1, 1988 Nitrogen mustard N-oxide hydrochloride 302705 April 1, 1988 Nitromethane 75525 May 1, 1997 2-Nitropropane 79469 January 1, 1988 1-Nitropyrene 5522430 October 1, 1990 4-Nitropyrene 57835924 October 1, 1990 N-Nitrosodi-n-butylamine 924163 October 1, 1987 N-Nitrosodiethanolamine 1116547 January 1, 1988 N-Nitrosodiethylamine 55185 October 1, 1987 N-Nitrosodimethylamine 62759 October 1, 1987 p-Nitrosodiphenylamine 156105 January 1, 1988 N-Nitrosodiphenylamine 86306 April 1, 1988 N-Nitrosodi-n-propylamine 621647 January 1, 1988 N-Nitroso-N-ethylurea 759739 October 1, 1987 3-(N-Nitrosomethylamino)propionitrile 60153493 April 1, 1990 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone 64091914 April 1, 1990 N-Nitrosomethylethylamine 10595956 October 1, 1989 N-Nitroso-N-methylurea 684935 October 1, 1987 N-Nitroso-N-methylurethane 615532 April 1, 1988 N-Nitrosomethylvinylamine 4549400 January 1, 1988 N-Nitrosomorpholine 59892 January 1, 1988 N-Nitrosonornicotine 16543558 January 1, 1988 N-Nitrosopiperidine 100754 January 1, 1988 N-Nitrosopyrrolidine 930552 October 1, 1987 N-Nitrososarcosine 13256229 January 1, 1988 o-Nitrotoluene 88722 May 15, 1998 Norethisterone (Norethindrone) 68224 October 1, 1989 Ochratoxin A 303479 July 1, 1990 Oil Orange SS 2646175 April 1, 1988 Oral contraceptives, combined --- October 1, 1989 Oral contraceptives, sequential --- October 1, 1989 Oxadiazon 19666309 July 1, 1991 Oxazepam 604751 October 1, 1994 Oxymetholone 434071 January 1, 1988 Oxythioquinox 2439012 August 20, 1999 Palygorskite fibers (> 5?m in length) 12174117 December 28, 1999 Panfuran S 794934 January 1, 1988 Pentachlorophenol 87865 January 1, 1990 Phenacetin 62442 October 1, 1989 Phenazopyridine 94780 January 1, 1988 Phenazopyridine hydrochloride 136403 January 1, 1988 Phenesterin 3546109 July 1, 1989 Phenobarbital 50066 January 1, 1990 Phenolphthalein 77098 May 15, 1998 Phenoxybenzamine 59961 April 1, 1988 Phenoxybenzamine hydrochloride 63923 April 1, 1988 o-Phenylenediamine and its salts 95545 May 15, 1998 Phenyl glycidyl ether 122601 October 1, 1990 Phenylhydrazine and its salts --- July 1, 1992 o-Phenylphenate, sodium 132274 January 1, 1990 PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) 105650235 October 1, 1994 Polybrominated biphenyls --- January 1, 1988 Polychlorinated biphenyls --- October 1, 1989 Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight) --- January 1, 1988 Polychlorinated dibenzo-p-dioxins --- October 1, 1992 Polychlorinated dibenzofurans --- October 1, 1992 Polygeenan 53973981 January 1, 1988 Ponceau MX 3761533 April 1, 1988 Ponceau 3R 3564098 April 1, 1988 Potassium bromate 7758012 January 1, 1990 Primidone 125337 August 20, 1999 Procarbazine 671169 January 1, 1988 Procarbazine hydrochloride 366701 January 1, 1988 Procymidone 32809168 October 1, 1994 Progesterone 57830 January 1, 1988 1,3-Propane sultone 1120714 January 1, 1988 Propargite 2312358 October 1, 1994 Pronamide 23950585 May 1, 1996 beta-Propiolactone 57578 January 1, 1988 Propylene oxide 75569 October 1, 1988 Propylthiouracil 51525 January 1, 1988 Quinoline and its strong acid salts --- October 24, 1997 Radionuclides --- July 1, 1989 Reserpine 50555 October 1, 1989 Residual (heavy) fuel oils --- October 1, 1990 Saccharin 81072 October 1, 1989 Saccharin, sodium 128449 January 1, 1988 Safrole 94597 January 1, 1988 Salicylazosulfapyridine 599791 May 15, 1998 Selenium sulfide 7446346 October 1, 1989 Shale-oils 68308349 April 1, 1990 Silica, crystalline (airborne particles of respirable size) --- October 1, 1988 Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) --- February 27, 1987 Spironolactone 52017 May 1, 1997 Stanozolol 10418038 May 1, 1997 Sterigmatocystin 10048132 April 1, 1988 Streptozotocin (streptozocin) 18883664 January 1, 1988 Styrene oxide 96093 October 1, 1988 Sulfallate 95067 January 1, 1988 Talc containing asbestiform fibers --- April 1, 1990 Tamoxifen and its salts 10540291 September 1, 1996 Terrazole 2593159 October 1, 1994 Testosterone and its esters 58220 April 1, 1988 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) 1746016 January 1, 1988 1,1,2,2-Tetrachloroethane 79345 July 1, 1990 Tetrachloroethylene (Perchloroethylene) 127184 April 1, 1988 p-a,a,a-Tetrachlorotoluene 5216251 January 1, 1990 Tetrafluoroethylene 116143 May 1, 1997 Tetranitromethane 509148 July 1, 1990 Thioacetamide 62555 January 1, 1988 4,4'-Thiodianiline 139651 April 1, 1988 Thiodicarb 59669260 August 20, 1999 Thiourea 62566 January 1, 1988 Thorium dioxide 1314201 February 27, 1987 Tobacco, oral use of smokeless products --- April 1, 1988 Tobacco smoke --- April 1, 1988 Toluene diisocyanate 26471625 October 1, 1989 ortho-Toluidine 95534 January 1, 1988 ortho-Toluidine hydrochloride 636215 January 1, 1988 para-Toluidine Delisted October 29, 1999 106490 January 1, 1990 Toxaphene (Polychlorinated camphenes) 8001352 January 1, 1988 Treosulfan 299752 February 27, 1987 Trichlormethine (Trimustine hydrochloride) 817094 January 1, 1992 Trichloroethylene 79016 April 1, 1988 2,4,6-Trichlorophenol 88062 January 1, 1988 1,2,3-Trichloropropane 96184 October 1,1992 Trimethyl phosphate 512561 May 1, 1996 2,4,5-Trimethylaniline and its strong acid salts --- October 24, 1997 Triphenyltin hydroxide 76879 July 1, 1992 Tris(aziridinyl)-para-benzoquinone (Triaziquone) 68768 October 1, 1989 Tris(1-aziridinyl)phosphine sulfide (Thiotepa) 52244 January 1, 1988 Tris(2-chloroethyl) phosphate 115968 April 1, 1992 Tris(2,3-dibromopropyl)phosphate 126727 January 1, 1988 Trp-P-1 (Tryptophan-P-1) 62450060 April 1, 1988 Trp-P-2 (Tryptophan-P-2) 62450071 April 1, 1988 Trypan blue (commercial grade) 72571 October 1, 1989 Unleaded gasoline (wholly vaporized) --- April 1, 1988 Uracil mustard 66751 April 1, 1988 Urethane (Ethyl carbamate) 51796 January 1, 1988 Vinclozolin 50471448 August 20, 1999 Vinyl bromide 593602 October 1, 1988 Vinyl chloride 75014 February 27, 1987 4-Vinylcyclohexene 100403 May 1, 1996 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) 106876 July 1, 1990 Vinyl fluoride 75025 May 1, 1997 Vinyl trichloride (1,1,2-Trichloroethane) 79005 October 1, 1990 2,6- Xylidine (2,6-Dimethylaniline) 87627 January 1, 1991 Zineb Delisted October 29, 1999 12122677 January 1, 1990 CHEMICALS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY Developmental toxicity Acetazolamide 59665 August 20, 1999 Acetohydroxamic acid 546883 April 1, 1990 Actinomycin D 50760 October 1, 1992 All-trans retinoic acid 302794 January 1, 1989 Alprazolam 28981977 July 1, 1990 Altretamine 645056 August 20, 1999 Amikacin sulfate 39831555 July 1, 1990 Aminoglutethimide 125848 July 1, 1990 Aminoglycosides --- October 1, 1992 Aminopterin 54626 July 1, 1987 Amiodarone hydrochloride 19774824 August 26, 1997 Amitraz 33089611 March 30, 1999 Amoxapine 14028445 May 15, 1998 Angiotensin converting enzyme (ACE) inhibitors --- October 1, 1992 Anisindione 117373 October 1, 1992 Arsenic (inorganic oxides) --- May 1, 1997 Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) 50782 July 1, 1990 Atenolol 29122687 August 26, 1997 Auranofin 34031328 January 29, 1999 Azathioprine 446866 September 1, 1996 Barbiturates --- October 1, 1992 Beclomethasone dipropionate 5534098 May 15, 1998 Benomyl 17804352 July 1, 1991 Benzene 71432 December 26, 1997 Benzphetamine hydrochloride 5411223 April 1, 1990 Benzodiazepines --- October 1, 1992 Bischloroethyl nitrosourea (BCNU) (Carmustine) 154938 July 1, 1990 Bromacil lithium salt 53404196 May 18, 1999 Bromoxynil 1689845 October 1, 1990 Bromoxynil octanoate 1689992 May 18, 1999 Butabarbital sodium 143817 October 1, 1992 1,4-Butanediol dimethanesulfonate (Busulfan) 55981 January 1, 1989 Cadmium --- May 1, 1997 Carbamazepine 298464 January 29, 1999 Carbon disulfide 75150 July 1, 1989 Carbon monoxide 630080 July 1, 1989 Carboplatin 41575944 July 1, 1990 Chenodiol 474259 April 1, 1990 Chinomethionat (Oxythioquinox) 2439012 November 6, 1998 Chlorambucil 305033 January 1, 1989 Chlorcyclizine hydrochloride 1620219 July 1, 1987 Chlordecone (Kepone) 143500 January 1, 1989 Chlordiazepoxide 58253 January 1, 1992 Chlordiazepoxide hydrochloride 438415 January 1, 1992 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) 13010474 July 1, 1990 Chlorsulfuron 64902723 May 14, 1999 Cidofovir 113852372 January 29, 1999 Cladribine 4291638 September 1, 1996 Clarithromycin 81103119 May 1, 1997 Clobetasol propionate 25122467 May 15, 1998 Clomiphene citrate 50419 April 1, 1990 Clorazepate dipotassium 57109907 October 1, 1992 Cocaine 50362 July 1, 1989 Codeine phosphate 52288 May 15, 1998 Colchicine 64868 October 1, 1992 Conjugated estrogens --- April 1, 1990 Cyanazine 21725462 April 1, 1990 Cycloate 1134232 March 19, 1999 Cycloheximide 66819 January 1, 1989 Cyclophosphamide (anhydrous) 50180 January 1, 1989 Cyclophosphamide (hydrated) 6055192 January 1, 1989 Cyhexatin 13121705 January 1, 1989 Cytarabine 147944 January 1, 1989 Dacarbazine 4342034 January 29, 1999 Danazol 17230885 April 1, 1990 Daunorubicin hydrochloride 23541506 July 1, 1990 2,4-D butyric acid 94826 June 18, 1999 o,p'-DDT 789026 May 15, 1998 p,p'-DDT 50293 May 15, 1998 2,4-DP (dichloroprop) 120365 April 27, 1999 Demeclocycline hydrochloride (internal use) 64733 January 1, 1992 Diazepam 439145 January 1, 1992 Dichlorophene 97234 April 27, 1999 Diclofop methyl 51338273 March 5, 1999 Dicumarol 66762 October 1, 1992 Diethylstilbestrol (DES) 56531 July 1, 1987 Diflunisal 22494424 January 29, 1999 Dihydroergotamine mesylate 6190392 May 1, 1997 Dinocap 39300453 April 1, 1990 Dinoseb 88857 January 1, 1989 Diphenylhydantoin (Phenytoin) 57410 July 1, 1987 Disodium cyanodithiomidocarbonate 138932 March 30, 1999 Doxorubicin hydrochloride 23214928 January 29, 1999 Doxycycline (internal use) 564250 July 1, 1990 Doxycycline calcium (internal use) 94088854 January 1, 1992 Doxycycline hyclate (internal use) 24390145 October 1, 1991 Doxycycline monohydrate (internal use) 17086281 October 1, 1991 Endrin 72208 May 15, 1998 Ergotamine tartrate 379793 April 1, 1990 Estropipate 7280377 August 26, 1997 Ethionamide 536334 August 26, 1997 Ethyl alcohol in alcoholic beverages --- October 1, 1987 Ethyl dipropylthiocarbamate 759944 April 27, 1999 Ethylene dibromide 106934 May 15, 1998 Ethylene glycol monoethyl ether 110805 January 1, 1989 Ethylene glycol monomethyl ether 109864 January 1, 1989 Ethylene glycol monoethyl ether acetate 111159 January 1, 1993 Ethylene glycol monomethyl ether acetate 110496 January 1, 1993 Ethylene thiourea 96457 January 1, 1993 Etodolac 41340254 August 20, 1999 Etoposide 33419420 July 1, 1990 Etretinate 54350480 July 1, 1987 Fenoxaprop ethyl 66441234 March 26, 1999 Fluazifop butyl 69806504 November 6, 1998 Flunisolide 3385033 May 15, 1998 Fluorouracil 51218 January 1, 1989 Fluoxymesterone 76437 April 1, 1990 Flurazepam hydrochloride 1172185 October 1, 1992 Flurbiprofen 5104494 August 20, 1999 Flutamide 13311847 July 1, 1990 Fluticasone propionate 80474142 May 15, 1998 Fluvalinate 69409945 November 6, 1998 Ganciclovir sodium 82410320 August 26, 1997 Goserelin acetate 65807025 August 26, 1997 Halazepam 23092173 July 1, 1990 Halobetasol propionate 66852548 August 20, 1999 Haloperidol 52868 January 29, 1999 Halothane 151677 September 1, 1996 Heptachlor 76448 August 20, 1999 Hexachlorobenzene 118741 January 1, 1989 Histrelin acetate --- May 15, 1998 Hydramethylnon 67485294 March 5, 1999 Hydroxyurea 127071 May 1, 1997 Idarubicin hydrochloride 57852570 August 20, 1999 Ifosfamide 3778732 July 1, 1990 Iodine-131 10043660 January 1, 1989 Isotretinoin 4759482 July 1, 1987 Lead --- February 27, 1987 Leuprolide acetate 74381536 August 26, 1997 Levodopa 59927 January 29, 1999 Linuron 330552 March 19, 1999 Lithium carbonate 554132 January 1, 1991 Lithium citrate 919164 January 1, 1991 Lorazepam 846491 July 1, 1990 Lovastatin 75330755 October 1, 1992 Mebendazole 31431397 August 20, 1999 Medroxyprogesterone acetate 71589 April 1, 1990 Megestrol acetate 595335 January 1, 1991 Melphalan 148823 July 1, 1990 Menotropins 9002680 April 1, 1990 Meprobamate 57534 January 1, 1992 Mercaptopurine 6112761 July 1, 1990 Mercury and mercury compounds --- July 1, 1990 Methacycline hydrochloride 3963959 January 1, 1991 Metham sodium 137428 May 15, 1998 Methazole 20354261 December 1, 1999 Methimazole 60560 July 1, 1990 Methotrexate 59052 January 1, 1989 Methotrexate sodium 15475566 April 1, 1990 Methyl bromide as a structural fumigant 74839 January 1, 1993 Methyl chloride 74873 March 10, 2000 Methyl mercury --- July 1, 1987 Methyltestosterone 58184 April 1, 1990 Metiram 9006422 March 30, 1999 Midazolam hydrochloride 59467968 July 1, 1990 Minocycline hydrochloride (internal use) 13614987 January 1, 1992 Misoprostol 59122462 April 1, 1990 Mitoxantrone hydrochloride 70476823 July 1, 1990 Myclobutanil 88671890 April 16, 1999 Nabam 142596 March 30, 1999 Nafarelin acetate 86220420 April 1, 1990 Neomycin sulfate (internal use) 1405103 October 1, 1992 Netilmicin sulfate 56391572 July 1, 1990 Nickel carbonyl 13463393 September 1, 1996 Nicotine 54115 April 1, 1990 Nifedipine 21829254 January 29, 1999 Nitrapyrin 1929824 March 30, 1999 Nitrogen mustard (Mechlorethamine) 51752 January 1, 1989 Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) 55867 July 1, 1990 Norethisterone (Norethindrone) 68224 April 1, 1990 Norethisterone acetate (Norethindrone acetate) 51989 October 1, 1991 Norethisterone (Norethindrone)/Ethinyl estradiol 68224/57636 April 1, 1990 Norethisterone (Norethindrone)/Mestranol 68224/72333 April 1, 1990 Norgestrel 6533002 April 1, 1990 Oxadiazon 19666309 May 15, 1998 Oxazepam 604751 October 1, 1992 Oxymetholone 434071 May 1, 1997 Oxytetracycline (internal use) 79572 January 1, 1991 Oxytetracycline hydrochloride (internal use) 2058460 October 1, 1991 Paclitaxel 33069624 August 26, 1997 Paramethadione 115673 July 1, 1990 Penicillamine 52675 January 1, 1991 Pentobarbital sodium 57330 July 1, 1990 Pentostatin 53910251 September 1, 1996 Phenacemide 63989 July 1, 1990 Phenprocoumon 435972 October 1, 1992 Pimozide 2062784 August 20, 1999 Pipobroman 54911 July 1, 1990 Plicamycin 18378897 April 1, 1990 Polybrominated biphenyls --- October 1, 1994 Polychlorinated biphenyls --- January 1, 1991 Potassium dimethyldithiocarbamate 128030 March 30 1999 Pravastatin sodium 81131706 March 3, 2000 Prednisolone sodium phosphate 125020 August 20, 1999 Procarbazine hydrochloride 366701 July 1, 1990 Propargite 2312358 June 15, 1999 Propylthiouracil 51525 July 1, 1990 Pyrimethamine 58140 January 29, 1999 Quazepam 36735225 August 26, 1997 Resmethrin 10453868 November 6, 1998 Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) --- July 1, 1989 Ribavirin 36791045 April 1, 1990 Secobarbital sodium 309433 October 1, 1992 Sermorelin acetate --- August 20, 1999 Sodium dimethyldithiocarbamate 128041 March 30 1999 Streptomycin sulfate 3810740 January 1, 1991 Streptozocin (streptozotocin) 18883664 August 20, 1999 Sulindac 38194502 January 29, 1999 Tamoxifen citrate 54965241 July 1, 1990 Temazepam 846504 April 1, 1990 Teniposide 29767202 September 1, 1996 Terbacil 5902512 May 18, 1999 Testosterone cypionate 58208 October 1, 1991 Testosterone enanthate 315377 April 1, 1990 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) 1746016 April 1, 1991 Tetracycline (internal use) 60548 October 1, 1991 Tetracyclines (internal use) --- October 1, 1992 Tetracycline hydrochloride (internal use) 64755 January 1, 1991 Thalidomide 50351 July 1, 1987 Thioguanine 154427 July 1, 1990 Tobacco smoke (primary) --- April 1, 1988 Tobramycin sulfate 49842071 July 1, 1990 Toluene 108883 January 1, 1991 Triadimefon 43121433 March 30, 1999 Triazolam 28911015 April 1, 1990 Tributyltin methacrylate 2155706 December 1, 1999 Triforine 26644462 37273840 June 18, 1999 Trilostane 13647353 April 1, 1990 Trimethadione 127480 January 1, 1991 Trimetrexate glucuronate 82952645 August 26, 1997 Uracil mustard 66751 January 1, 1992 Urethane 51796 October 1, 1994 Urofollitropin 26995915 April 1, 1990 Valproate (Valproic acid) 99661 July 1, 1987 Vinblastine sulfate 143679 July 1, 1990 Vinclozolin 50471448 May 15, 1998 Vincristine sulfate 2068782 July 1, 1990 Warfarin 81812 July 1, 1987 Female reproductive toxicity Aminopterin 54626 July 1, 1987 Amiodarone hydrochloride 19774824 August 26, 1997 Anabolic steroids --- April 1, 1990 Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) 50782 July 1, 1990 Carbon disulfide 75150 July 1, 1989 Cidofovir 113852372 January 29, 1999 Chlorsulfuron 64902723 May 14, 1999 Clobetasol propionate 25122467 May 15, 1998 Cocaine 50362 July 1, 1989 Cyclophosphamide (anhydrous) 50180 January 1, 1989 Cyclophosphamide (hydrated) 6055192 January 1, 1989 o,p'-DDT 789026 May 15, 1998 p,p'-DDT 50293 May 15, 1998 Diflunisal 22494424 January 29, 1999 Dinitrotoluene (technical grade) --- August 20, 1999 Ethylene oxide 75218 February 27, 1987 Etodolac 41340254 August 20, 1999 Flunisolide 3385033 May 15, 1998 Flurbiprofen 5104494 August 20, 1999 Gemfibrozil 25812300 August 20, 1999 Goserelin acetate 65807025 August 26, 1997 Haloperidol 52868 January 29, 1999 Lead --- February 27, 1987 Leuprolide acetate 74381536 August 26, 1997 Levonorgestrel implants 797637 May 15, 1998 Nifedipine 21829254 January 29, 1999 Oxydemeton methyl 301122 November 6, 1998 Paclitaxel 33069624 August 26, 1997 Pimozide 2062784 August 20, 1999 Streptozocin (streptozotocin) 18883664 August 20, 1999 Sulindac 38194502 January 29, 1999 Thiophanate methyl 23564058 May 18, 1999 Tobacco smoke (primary) --- April 1, 1988 Triadimefon 43121433 March 30, 1999 Uracil mustard 66751 January 1, 1992 Male reproductive toxicity Altretamine 645056 August 20, 1999 Amiodarone hydrochloride 19774824 August 26, 1997 Anabolic steroids --- April 1, 1990 Benomyl 17804352 July 1, 1991 Benzene 71432 December 26, 1997 Cadmium --- May 1, 1997 Carbon disulfide 75150 July 1, 1989 Cidofovir 113852372 January 29, 1999 Chlorsulfuron 64902723 May 14, 1999 Colchicine 64868 October 1, 1992 Cyclohexanol 108930 November 6, 1998 Cyclophosphamide (anhydrous) 50180 January 1, 1989 Cyclophosphamide (hydrated) 6055192 January 1, 1989 2,4-D butyric acid 94826 June 18, 1999 o,p'-DDT 789026 May 15, 1998 p,p'-DDT 50293 May 15, 1998 1,2-Dibromo-3-chloropropane (DBCP) 96128 February 27, 1987 m-Dinitrobenzene 99650 July 1, 1990 o-Dinitrobenzene 528290 July 1, 1990 p-Dinitrobenzene 100254 July 1, 1990 2,4-Dinitrotoluene 121142 August 20, 1999 2,6-Dinitrotoluene 606202 August 20, 1999 Dinitrotoluene (technical grade) --- August 20, 1999 Dinoseb 88857 January 1, 1989 Doxorubicin hydrochloride 23214928 January 29, 1999 Epichlorohydrin 106898 September 1, 1996 Ethylene dibromide 106934 May 15, 1998 Ethylene glycol monoethyl ether 110805 January 1, 1989 Ethylene glycol monomethyl ether 109864 January 1, 1989 Ethylene glycol monoethyl ether acetate 111159 January 1, 1993 Ethylene glycol monomethyl ether acetate 110496 January 1, 1993 Ganciclovir sodium 82410320 August 26, 1997 Gemfibrozil 25812300 August 20, 1999 Goserelin acetate 65807025 August 26, 1997 Hexamethylphosphoramide 680319 October 1, 1994 Hydramethylnon 67485294 March 5, 1999 Idarubicin hydrochloride 57852570 August 20, 1999 Lead --- February 27, 1987 Leuprolide acetate 74381536 August 26, 1997 Myclobutanil 88671890 April 16, 1999 Nifedipine 21829254 January 29, 1999 Nitrofurantoin 67209 April 1, 1991 Oxydemeton methyl 301122 November 6, 1998 Paclitaxel 33069624 August 26, 1997 Quizalofop-ethyl 76578148 December 24, 1999 Sodium fluoroacetate 62748 November 6, 1998 Streptozocin (streptozotocin) 18883664 August 20, 1999 Sulfasalazine 599791 January 29, 1999 Thiophanate methyl 23564058 May 18, 1999 Tobacco smoke (primary) --- April 1, 1988 Triadimefon 43121433 March 30, 1999 Uracil mustard 66751 January 1, 1992 Date: June 2, 2000 -3- 3