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The Office of Environmental Health Hazard Assessment (OEHHA)
of the California Environmental Protection Agency has added 18 chemicals
to the list of chemicals known to the State to cause cancer or reproductive
toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement
Act of 1986 (Proposition 65 or the Act). These chemicals are listed
effective August 26, 1997. Two of these chemicals, however,
C.I. Direct Blue 15 and C.I. Direct Blue 218, are "benzidine-based
dyes" and, as such, have been subject to the provisions of
Proposition 65 since the October 1, 1992 listing date.
The listing of these two dyes is to provide specificity to the existing
categorical listing of benzidine-based dyes.
The 18 chemicals are listed pursuant to the administrative mechanisms
for listing provided under the Act, based upon either (1) a formal
identification by an authoritative body that the chemical causes
cancer or reproductive toxicity; or, (2) a formal requirement by
a state or federal agency that the chemical be identified or labeled
as causing cancer or reproductive toxicity. Regulations governing
the listing of chemicals under the "authoritative bodies"
mechanism and the "formally required to be labeled or identified"
mechanism are published in Title 22, California Code of Regulations,
Sections 12306 and 12902, respectively.
The reader is directed to the Notice of Intent to List Chemicals
published in the June 27, 1997 issue of the California Regulatory
Notice Register for the supporting documentation which OEHHA relied
upon in making its determination that the criteria for administrative
listing have been satisfied.
The 16 chemicals listed effective August 26, 1997, and the mechanism
under which each is listed, are shown below:
Carcinogens
| Chemical |
CAS No. |
Listing Mechanism1 |
| 1-Amino-2,4-dibromoanthraquinone |
81-49-2 |
AB |
| 3,7-Dinitrofluoranthene |
105735-71-5 |
AB |
| 3,9-Dinitrofluoranthene |
22506-53-2 |
AB |
| Nitrobenzene |
98-95-3 |
AB |
| Estropipate |
7280-37-7 |
FR |
| Ganciclovir sodium |
82410-32-0 |
FR |
Reproductive toxicants:
| Chemical |
Type of Reproductive Toxicity
|
CAS No. |
Listing Mechanism1
|
| Amiodarone hydrochloride |
Male reproductive toxicity
Female reproductive toxicity
Developmental toxicity
|
19774-82-4 |
FR |
| Atenolol |
Developmental toxicity |
29122-68-7 |
FR |
| Estropipate |
Developmental toxicity |
7280-37-7 |
FR |
| Ethionamide |
Developmental toxicity |
536-33-4 |
FR |
| Ganciclovir sodium |
Male reproductive toxicity
Developmental toxicity
|
82410-32-0 |
FR |
| Goserelin acetate |
Male reproductive toxicity
Female reproductive toxicity
Developmental toxicity
|
65807-02-5 |
FR |
| Leuprolide acetate |
Male reproductive toxicity
Female reproductive toxicity
Developmental toxicity
|
74381-53-6 |
FR |
| Paclitaxel |
Male reproductive toxicity
Female reproductive toxicity
Developmental toxicity
|
33069-62-4 |
FR |
| Quazepam |
Developmental toxicity |
36735-22-5 |
FR |
| Trimetrexate glucuronate |
Developmental toxicity |
82952-64-5 |
FR |
The 2 chemicals which were already listed as carcinogens as of
October 1, 1992, and the mechanism under which each is listed, are
shown below:
| Chemical |
CAS No. |
Listing Mechanism1 |
| C.I. Direct Blue 15 |
2429-74-5 |
AB |
| C.I. Direct Blue 218 |
28407-37-6 |
AB |
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1. Listing mechanism:
AB - "authoritative bodies" mechanism (Section 12306)
FR - "formally required to be labeled or identified" mechanism
(Section 12902)
Follow this link to download a complete
Proposition 65 list dated August 26, 1997.
You will need the free program Adobe Acrobat Reader to view or
print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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