STATE OF CALIFORNIA
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT
SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY

August 04, 2000

The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout are chemicals recommended for removal from the list by the "state’s qualified experts."

CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER
(Sorted by CAS number)

Chemical

CAS Number

Date

2,4,5-Trimethylaniline and its strong acid salts

---

Oct 24, 1997

5-Chloro-o-toluidine and its strong acid salts

---

Oct 24, 1997

Aflatoxins

---

Jan 1, 1988

Alcoholic beverages, when associated with alcohol abuse

---

July 1, 1988

Analgesic mixtures containing phenacetin

---

Feb 27, 1987

Arsenic (inorganic arsenic compounds)

---

Feb 27, 1987

Benzidine-based dyes

---

Oct 1, 1992

Beryllium and beryllium compounds

---

Oct 1, 1987

Betel quid with tobacco

---

Jan 1, 1990

Bis(2-chloro-1-methylethyl)ether, technical grade

---

Oct 29, 1999

Bitumens, extracts of steam-refined and air refined

---

Jan 1, 1990

Bracken fern

---

Jan 1, 1990

Cadmium and cadmium compounds

---

Oct 1, 1987

Carbon-black extracts

---

Jan 1, 1990

Ceramic fibers (airborne particles of respirable size)

---

July 1, 1990

Certain combined chemotherapy for lymphomas

---

Feb 27, 1987

Chromium (hexavalent compounds)

---

Feb 27, 1987

Coke oven emissions

---

Feb 27, 1987

Conjugated estrogens

---

Feb 27, 1987

Creosotes

---

Oct 1, 1988

Diaminotoluene (mixed)

---

Jan 1, 1990

Diesel engine exhaust

---

Oct 1, 1990

Dinitrotoluene mixture, 2,4-/2,6-

---

May 1, 1996

Gasoline engine exhaust (condensates/extracts)

---

Oct 1, 1990

Glasswool fibers (airborne particles of respirable size)

---

July 1, 1990

Hexachlorocyclohexane (technical grade)

---

Oct 1, 1987

Lead and lead compounds

---

Oct 1, 1992

Lindane and other hexachlorocyclohexane isomers

---

Oct 1, 1989

Methylhydrazine and its salts

---

July 1, 1992

Methylmercury compounds

---

May 1, 1996

Nickel and certain nickel compounds

---

Oct 1, 1989

Nickel refinery dust from the pyrometallurgical process

---

Oct 1, 1987

Oral contraceptives, combined

---

Oct 1, 1989

Oral contraceptives, sequential

---

Oct 1, 1989

p-Chloro-o-toluidine, strong acid salts of

---

May 15, 1998

Phenylhydrazine and its salts

---

July 1, 1992

Polybrominated biphenyls

---

Jan 1, 1988

Polychlorinated biphenyls

---

Oct 1, 1989

Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight)

---

Jan 1, 1988

Polychlorinated dibenzofurans

---

Oct 1, 1992

Polychlorinated dibenzo-p-dioxins

---

Oct 1, 1992

Quinoline and its strong acid salts

---

Oct 24, 1997

Radionuclides

---

July 1, 1989

Residual (heavy) fuel oils

---

Oct 1, 1990

Silica, crystalline (airborne particles of respirable size)

---

Oct 1, 1988

Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils)

---

Feb 27, 1987

Talc containing asbestiform fibers

---

April 1, 1990

Tobacco smoke

---

April 1, 1988

Tobacco, oral use of smokeless products

---

April 1, 1988

Unleaded gasoline (wholly vaporized)

---

April 1, 1988

Ciclosporin (Cyclosporin A; Cyclosporine)

59865133/79217600

Jan 1, 1992

Formaldehyde (gas)

50000

Jan 1, 1988

Phenobarbital

50066

Jan 1, 1990

Mitomycin C

50077

April 1, 1988

Cyclophosphamide (anhydrous)

50180

Feb 27, 1987

Estradiol 17B

50282

Jan 1, 1988

DDT (Dichlorodiphenyltrichloroethane)

50293

Oct 1, 1987

Benzo[a]pyrene

50328

July 1, 1987

Reserpine

50555

Oct 1, 1989

Actinomycin D

50760

Oct 1, 1989

Propylthiouracil

51525

Jan 1, 1988

Nitrogen mustard (Mechlorethamine)

51752

Jan 1, 1988

Urethane (Ethyl carbamate)

51796

Jan 1, 1988

Spironolactone

52017

May 1, 1997

Tris(1-aziridinyl)phosphine sulfide (Thiotepa)

52244

Jan 1, 1988

Estrone

53167

Jan 1, 1988

Dibenz[a,h]anthracene

53703

Jan 1, 1988

2-Acetylaminofluorene

53963

July 1, 1987

N-Nitrosodiethylamine

55185

Oct 1, 1987

Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride)

55867

April 1, 1988

1,4-Butanediol dimethanesulfonate (Busulfan)

55981

Feb 27, 1987

Methylthiouracil

56042

Oct 1, 1989

Carbon tetrachloride

56235

Oct 1, 1987

3-Methylcholanthrene

56495

Jan 1, 1990

Diethylstilbestrol (DES)

56531

Feb 27, 1987

Benz[a]anthracene

56553

July 1, 1987

Chloramphenicol

56757

Oct 1, 1989

1,1-Dimethylhydrazine (UDMH)

57147

Oct 1, 1989

Diphenylhydantoin (Phenytoin)

57410

Jan 1, 1988

beta-Propiolactone

57578

Jan 1, 1988

Ethinylestradiol

57636

Jan 1, 1988

Chlordane

57749

July 1, 1988

Progesterone

57830

Jan 1, 1988

7,12-Dimethylbenz(a)anthracene

57976

Jan 1, 1990

Testosterone and its esters

58220

April 1, 1988

Nitrofurazone

59870

Jan 1, 1990

N-Nitrosomorpholine

59892

Jan 1, 1988

Phenoxybenzamine

59961

April 1, 1988

p-Aminoazobenzene

60093

Jan 1, 1990

4-Dimethylaminoazobenzene

60117

Jan 1, 1988

Acetamide

60355

Jan 1, 1990

Dieldrin

60571

July 1, 1988

Niridazole

61574

April 1, 1988

Amitrole

61825

July 1, 1987

Phenacetin

62442

Oct 1, 1989

Ethyl methanesulfonate

62500

Jan 1, 1988

Aniline

62533

Jan 1, 1990

Thioacetamide

62555

Jan 1, 1988

Thiourea

62566

Jan 1, 1988

DDVP (Dichlorvos)

62737

Jan 1, 1989

N-Nitrosodimethylamine

62759

Oct 1, 1987

Phenoxybenzamine hydrochloride

63923

April 1, 1988

Diethyl sulfate

64675

Jan 1, 1988

Methyl methanesulfonate

66273

April 1, 1988

Uracil mustard

66751

April 1, 1988

Furazolidone

67458

Jan 1, 1990

Chloroform

67663

Oct 1, 1987

Hexachloroethane

67721

July 1, 1990

Norethisterone (Norethindrone)

68224

Oct 1, 1989

Tris(aziridinyl)-para-benzoquinone (Triaziquone)

68768

Oct 1, 1989

N-Methyl-N'-nitro-N-nitrosoguanidine

70257

April 1, 1988

Benzene

71432

Feb 27, 1987

Medroxyprogesterone acetate

71589

Jan 1, 1990

Mestranol

72333

April 1, 1988

Fenoxycarb 72490-01-8 June 02, 2000

DDD (Dichlorodiphenyldichloroethane)

72548

Jan 1, 1989

DDE (Dichlorodiphenyldichloroethylene)

72559

Jan 1, 1989

Trypan blue (commercial grade)

72571

Oct 1, 1989

Methyl iodide

74884

April 1, 1988

Chloroethane (Ethyl chloride)

75003

July 1, 1990

Vinyl chloride

75014

Feb 27, 1987

Vinyl fluoride

75025

May 1, 1997

Acetaldehyde

75070

April 1, 1988

Dichloromethane (Methylene chloride)

75092

April 1, 1988

Ethylene oxide

75218

July 1, 1987

Bromoform

75252

April 1, 1991

Bromodichloromethane

75274

Jan 1, 1990

1,1-Dichloroethane

75343

Jan 1, 1990

Nitromethane

75525

May 1, 1997

2-Methylaziridine (Propyleneimine)

75558

Jan 1, 1988

Propylene oxide

75569

Oct 1, 1988

Cacodylic acid

75605

May 1, 1996

Heptachlor

76448

July 1, 1988

Triphenyltin hydroxide

76879

July 1, 1992

Phenolphthalein

77098

May 15, 1998

Dimethyl sulfate

77781

Jan 1, 1988

Isoprene

78795

May 1, 1996

1,2-Dichloropropane

78875

Jan 1, 1990

Vinyl trichloride (1,1,2-Trichloroethane)

79005

Oct 1, 1990

Trichloroethylene

79016

April 1, 1988

Acrylamide

79061

Jan 1, 1990

1,1,2,2-Tetrachloroethane

79345

July 1, 1990

Dichloroacetic acid

79436

May 1, 1996

Dimethylcarbamoyl chloride

79447

Jan 1, 1988

2-Nitropropane

79469

Jan 1, 1988

Saccharin

81072

Oct 1, 1989

1-Amino-2,4-dibromoanthraquinone

81492

Aug 26, 1997

D&C Red No. 19

81889

July 1, 1990

1-Amino-2-methylanthraquinone

82280

Oct 1, 1989

Dienestrol

84173

Jan 1, 1990

N-Nitrosodiphenylamine

86306

April 1, 1988

Carbazole

86748

May 1, 1996

Cinnamyl anthranilate

87296

July 1, 1989

2,6- Xylidine (2,6-Dimethylaniline)

87627

Jan 1, 1991

Pentachlorophenol

87865

Jan 1, 1990

2,4,6-Trichlorophenol

88062

Jan 1, 1988

o-Nitrotoluene

88722

May 15, 1998

ortho-Anisidine

90040

July 1, 1987

o-Phenylphenol 90437 Aug 04, 2000

Michler's ketone

90948

Jan 1, 1988

o-Nitroanisole

91236

Oct 1, 1992

2-Naphthylamine

91598

Feb 27, 1987

3,3'-Dichlorobenzidine

91941

Oct 1, 1987

4-Aminobiphenyl (4-aminodiphenyl)

92671

Feb 27, 1987

Benzidine [and its salts]

92875

Feb 27, 1987

4-Nitrobiphenyl

92933

April 1, 1988

Dihydrosafrole

94586

Jan 1, 1988

Safrole

94597

Jan 1, 1988

Phenazopyridine

94780

Jan 1, 1988

Sulfallate

95067

Jan 1, 1988

ortho-Toluidine

95534

Jan 1, 1988

o-Phenylenediamine and its salts

95545

May 15, 1998

p-Chloro-o-toluidine

95692

Jan 1, 1990

2,4-Diaminotoluene

95807

Jan 1, 1988

4-Chloro-ortho-phenylenediamine

95830

Jan 1, 1988

Styrene oxide

96093

Oct 1, 1988

1,2-Dibromo-3-chloropropane (DBCP)

96128

July 1, 1987

2,3-Dibromo-1-propanol

96139

Oct 1, 1994

1,2,3-Trichloropropane

96184

Oct 1,1992

Ethylene thiourea

96457

Jan 1, 1988

ortho-Aminoazotoluene

97563

July 1, 1987

Benzotrichloride

98077

July 1, 1987

Nitrobenzene

98953

Aug 26, 1997

5-Nitro-o-anisidine

99592

Oct 1, 1989

1-Chloro-4-nitrobenzene

100005

Oct 29, 1999

Cobalt sulfate heptahydrate 10026-24-1 June 02, 2000

4-Vinylcyclohexene

100403

May 1, 1996

Benzyl chloride

100447

Jan 1, 1990

N-Nitrosopiperidine

100754

Jan 1, 1988

4,4'-Methylene bis(2-chloroaniline)

101144

July 1, 1987

4,4'-Methylene bis(N,N-dimethyl)benzenamine

101611

Oct 1, 1989

4,4'-Methylenedianiline

101779

Jan 1, 1988

4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline)

101804

Jan 1, 1988

Diglycidyl resorcinol ether (DGRE)

101906

July 1, 1989

Azobenzene

103333

Jan 1, 1990

p-Dichlorobenzene

106467

Jan 1, 1989

p-Chloroaniline

106478

Oct 1, 1994

para-Toluidine Delisted Oct 29, 1999

106490

Jan 1, 1990

4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide)

106876

July 1, 1990

Epichlorohydrin

106898

Oct 1, 1987

Ethylene dibromide

106934

July 1, 1987

1,3-Butadiene

106990

April 1, 1988

Allyl chloride Delisted Oct 29, 1999

107051

Jan 1, 1990

Ethylene dichloride (1,2-Dichloroethane)

107062

Oct 1, 1987

Acrylonitrile

107131

July 1, 1987

Chloromethyl methyl ether (technical grade)

107302

Feb 27, 1987

Furan

110009

Oct 1, 1993

Bis(2-chloroethyl)ether

111444

April 1, 1988

Azaserine

115026

July 1, 1987

Chlorendic acid

115286

July 1, 1989

Tris(2-chloroethyl) phosphate

115968

April 1, 1992

Tetrafluoroethylene

116143

May 1, 1997

Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)

117102

Jan 1, 1992

2-Aminoanthraquinone

117793

Oct 1, 1989

Di(2-ethylhexyl)phthalate

117817

Jan 1, 1988

Hexachlorobenzene

118741

Oct 1, 1987

4-Amino-2-nitrophenol

119346

Jan 29, 1999

3,3'-Dimethoxybenzidine (ortho-Dianisidine)

119904

Jan 1, 1988

3,3'-Dimethylbenzidine (ortho-Tolidine)

119937

Jan 1, 1988

Isosafrole

120581

Oct 1, 1989

para-Cresidine

120718

Jan 1, 1988

2,4-Dinitrotoluene

121142

July 1, 1988

Phenyl glycidyl ether

122601

Oct 1, 1990

Hydrazobenzene (1,2-Diphenylhydrazine)

122667

Jan 1, 1988

1,4-Dioxane

123911

Jan 1, 1988

Chlorodibromomethane Delisted Oct 29, 1999

124481

Jan 1, 1990

Primidone

125337

Aug 20, 1999

Griseofulvin

126078

Jan 1, 1990

Tris(2,3-dibromopropyl)phosphate

126727

Jan 1, 1988

Nitrogen mustard N-oxide

126852

April 1, 1988

Chloroprene 126998 June 02, 2000

Tetrachloroethylene (Perchloroethylene)

127184

April 1, 1988

Saccharin, sodium

128449

Jan 1, 1988

2-Methyl-1-nitroanthraquinone (of uncertain purity)

129157

April 1, 1988

o-Phenylphenate, sodium

132274

Jan 1, 1990

Captan

133062

Jan 1, 1990

Folpet

133073

Jan 1, 1989

ortho-Anisidine hydrochloride

134292

July 1, 1987

1-Naphthylamine

134327

Oct 1, 1989

Cupferron

135206

Jan 1, 1988

Phenazopyridine hydrochloride

136403

Jan 1, 1988

Di-n-propyl isocinchomeronate (MGK Repellent 326)

136458

May 1, 1996

Metham sodium

137428

Nov 6, 1998

Nitrilotriacetic acid

139139

Jan 1, 1988

4,4'-Thiodianiline

139651

April 1, 1988

5-(Morpholinomethyl)-3-[(5-nitro-furfurylidene)-amino]-2-oxazolidinone

139913

April 1, 1988

Aramite

140578

July 1, 1987

Estragole

140670

Oct 29, 1999

Ethyl acrylate

140885

July 1, 1989

Aniline hydrochloride

142041

May 15, 1998

Chlordecone (Kepone)

143500

Jan 1, 1988

Melphalan

148823

Feb 27, 1987

Ethyleneimine

151564

Jan 1, 1988

2-Aminofluorene

153786

Jan 29, 1999

Bischloroethyl nitrosourea (BCNU) (Carmustine)

154938

July 1, 1987

p-Nitrosodiphenylamine

156105

Jan 1, 1988

Dibenzo[a,i]pyrene

189559

Jan 1, 1988

Dibenzo[a,h]pyrene

189640

Jan 1, 1988

Dibenzo[a,l]pyrene

191300

Jan 1, 1988

Dibenzo[a,e]pyrene

192654

Jan 1, 1988

Indeno [1,2,3-cd]pyrene

193395

Jan 1, 1988

7H-Dibenzo[c,g]carbazole

194592

Jan 1, 1988

Benzo[j]fluoranthene

205823

July 1, 1987

Benzo[b]fluoranthene

205992

July 1, 1987

Benzo[k]fluoranthene

207089

July 1, 1987

Chrysene

218019

Jan 1, 1990

Dibenz[a,j]acridine

224420

Jan 1, 1988

Dibenz[a,h]acridine

226368

Jan 1, 1988

Benzofuran

271896

Oct 1, 1990

8-Methoxypsoralen with ultraviolet A therapy

298817

Feb 27, 1987

Treosulfan

299752

Feb 27, 1987

Lead acetate

301042

Jan 1, 1988

Hydrazine

302012

Jan 1, 1988

Nitrogen mustard N-oxide hydrochloride

302705

April 1, 1988

Lasiocarpine

303344

April 1, 1988

Ochratoxin A

303479

July 1, 1990

Chlorambucil

305033

Feb 27, 1987

Aldrin

309002

July 1, 1988

Monocrotaline

315220

April 1, 1988

Azacitidine

320672

Jan 1, 1992

Caffeic acid

331395

Oct 1, 1994

Procarbazine hydrochloride

366701

Jan 1, 1988

Nalidixic acid

389082

May 15, 1998

Oxymetholone

434071

Jan 1, 1988

Metronidazole

443481

Jan 1, 1988

Azathioprine

446866

Feb 27, 1987

5-Methoxypsoralen with ultraviolet A therapy

484208

Oct 1, 1988

Auramine

492808

July 1, 1987

N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine)

494031

Feb 27, 1987

Mustard Gas

505602

Feb 27, 1987

Tetranitromethane

509148

July 1, 1990

Ethyl-4,4'-dichlorobenzilate

510156

Jan 1, 1990

Trimethyl phosphate

512561

May 1, 1996

Dimethylvinylchloride

513371

July 1, 1989

Merphalan

531760

April 1, 1988

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide

531828

April 1, 1988

1,2-Dimethylhydrazine

540738

Jan 1, 1988

Isobutyl nitrite

542563

May 1, 1996

1,3-Dichloropropene

542756

Jan 1, 1989

Bis(chloromethyl)ether

542881

Feb 27, 1987

1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone

555840

April 1, 1988

Glycidol

556525

July 1, 1990

3-Chloro-2-methylpropene

563473

July 1, 1989

Chlorotrianisene

569573

Sept 1, 1996

C.I. Basic Red 9 monohydrochloride

569619

July 1, 1989

Methylazoxymethanol

590965

April 1, 1988

Methylazoxymethanol acetate

592621

April 1, 1988

Vinyl bromide

593602

Oct 1, 1988

Methyl carbamate

598550

May 15, 1998

Salicylazosulfapyridine

599791

May 15, 1998

5-Nitroacenaphthene

602879

April 1, 1988

Oxazepam

604751

Oct 1, 1994

2,6-Dinitrotoluene

606202

July 1, 1995

2-Nitrofluorene

607578

Oct 1, 1990

3,3'-Dimethylbenzidine dihydrochloride

612828

April 1, 1992

3,3¢ -Dichlorobenzidine dihydrochloride

612839

May 15, 1998

N,N'-Diacetylbenzidine

613354

Oct 1, 1989

2,4-Diaminoanisole

615054

Oct 1, 1990

N-Nitroso-N-methylurethane

615532

April 1, 1988

N-Nitrosodi-n-propylamine

621647

Jan 1, 1988

Diphenylhydantoin (Phenytoin), sodium salt

630933

Jan 1, 1988

ortho-Toluidine hydrochloride

636215

Jan 1, 1988

Clofibrate

637070

Sept 1, 1996

Procarbazine

671169

Jan 1, 1988

Hexamethylphosphoramide

680319

Jan 1, 1988

N-Nitroso-N-methylurea

684935

Oct 1, 1987

2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole

712685

July 1, 1987

N-Nitroso-N-ethylurea

759739

Oct 1, 1987

1,4-Dichloro-2-butene

764410

Jan 1, 1990

Glycidaldehyde

765344

Jan 1, 1988

Panfuran S

794934

Jan 1, 1988

Trichlormethine (Trimustine hydrochloride)

817094

Jan 1, 1992

4,4'-Methylene bis(2-methylaniline)

838880

April 1, 1988

C.I. Solvent Yellow 14

842079

May 15, 1998

N-Nitrosodi-n-butylamine

924163

Oct 1, 1987

N-Methylolacrylamide

924425

July 1, 1990

N-Nitrosopyrrolidine

930552

Oct 1, 1987

Heptachlor epoxide

1024573

July 1, 1988

N-Nitrosodiethanolamine

1116547

Jan 1, 1988

1,3-Propane sultone

1120714

Jan 1, 1988

Cobalt [II] oxide

1307966

July 1, 1992

Antimony oxide (Antimony trioxide)

1309644

Oct 1, 1990

Thorium dioxide

1314201

Feb 27, 1987

Asbestos

1332214

Feb 27, 1987

Lead subacetate

1335326

Oct 1, 1989

Diepoxybutane

1464535

Jan 1, 1988

Daminozide

1596845

Jan 1, 1990

1,2-Diethylhydrazine

1615801

Jan 1, 1988

Benzyl violet 4B

1694093

July 1, 1987

2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD)

1746016

Jan 1, 1988

Nitrofen (technical grade)

1836755

Jan 1, 1988

Chlorothalonil

1897456

Jan 1, 1989

Direct Black 38 (technical grade)

1937377

Jan 1, 1988

D&C Red No. 8

2092560

Oct 1, 1990

Propargite

2312358

Oct 1, 1994

Mirex

2385855

Jan 1, 1988

Captafol

2425061

Oct 1, 1988

C.I. Direct Blue 15

2429745

Aug 26, 1997

Oxythioquinox

2439012

Aug 20, 1999

Disperse Blue 1

2475458

Oct 1, 1990

Terrazole

2593159

Oct 1, 1994

Direct Blue 6 (technical grade)

2602462

Jan 1, 1988

Oil Orange SS

2646175

April 1, 1988

HC Blue 1

2784943

July 1, 1989

Diisopropyl sulfate

2973106

April 1, 1993

beta-Butyrolactone

3068880

July 1, 1987

2,2-Bis(bromomethyl)-1,3-propanediol

3296900

May 1, 1996

D&C Orange No. 17

3468631

July 1, 1990

Phenesterin

3546109

July 1, 1989

Ponceau 3R

3564098

April 1, 1988

2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole

3570750

Jan 1, 1988