EXECUTIVE SUMMARY

Allyl isovalerate is a branched-chain allyl ester compound with potential human exposures stemming from its use as an approved flavoring agent. Quantitative estimates of current exposure to allyl isovalerate are difficult since the addition of the compound to food products may be up to the level required to produce its intended effect, reporting is not required, and available data are somewhat dated. Based on levels reported in some food, personal hygiene and cosmetics products, exposure to low levels of the compound may be expected to be widespread.
There is evidence for the carcinogenicity of allyl isovalerate, with the development of hematopoietic tumors in male rats and female mice treated for two years by oral gavage. Further evidence includes observations of genotoxicity in short-term tests in mammalian cells and possible metabolism to a carcinogenic compound.

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