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The California Environmental Protection Agencys Office of
Environmental Health Hazard Assessment (OEHHA), as lead agency for
the implementation of the Safe Drinking Water and Toxic Enforcement
Act of 1986 (Proposition 65), has developed a procedure for prioritizing
chemicals for consideration under Proposition 65 by the "States
qualified experts". Two committees of the Science Advisory
Board (SAB), known as the Carcinogen Identification Committee, and
the Developmental and Reproductive Toxicant (DART) Identification
Committee, serve as the States qualified experts for rendering
an opinion as to whether a chemical is known to the State to cause
cancer, birth defects or other reproductive harm.
The procedure used by OEHHA to identify, prioritize and select
candidate chemicals for evaluation by the SAB Committees is described
in, "Procedure for Prioritizing Candidate Chemicals for Consideration
Under Proposition 65 by the States Qualified Experts," May 1997,
and is available on the Internet at www.oehha.ca.gov.
On October 3, 1997, OEHHA announced the release of draft priority
assignments and draft data summaries for 28 of 30 chemicals selected
for prioritization with respect to their potential to cause cancer.
(Prioritization of two of the 30 chemicals, C.I. solvent yellow
14 and salicylazosulfapyridine, was postponed; both were listed
as causing cancer on May 15, 1998 via the authoritative
bodies listing mechanism of Proposition 65.) The October 3, 1997
announcement initiated a 60-day public comment period, which included
a public workshop held November 18, 1997. After review and careful
consideration of the comments received, the priority assignments
have been finalized. The only final priority which differs from
the draft assignment is for furfural, for which the final priority
is "medium high".
In accordance with OEHHAs prioritization procedure, all chemicals
with final priority assignments of "high" carcinogenicity
concern are placed on the final Candidate List (Table 2). All other
final prioritized chemicals will be placed in Category II. Chemicals
are selected from the Candidate List for the development of draft
hazard identification documents and subsequent consideration for
listing by the Carcinogen Identification Committee of OEHHAs
Science Advisory Board. The final priority assignments for the 28
chemicals are given below in Table 1.
Table 1. Final Priority Assignments
| CHEMICAL |
CASRN
|
FINAL PRIORITY
|
| p-chloronitrobenzene |
100-00-5
|
High
|
| estragole |
140-67-0
|
High
|
| trichloroacetic acid |
76-03-9
|
High
|
| bis(2-chloro-1-methylethyl)ether |
108-60-1
|
High
|
| 2-aminofluorene |
153-78-6
|
High
|
| 4-amino-2-nitrophenol |
119-34-6
|
High
|
| acronycine |
7008-42-6
|
High
|
| 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole |
3775-55-1
|
High
|
| N-butyl-N-nitrosourea |
869-01-2
|
High
|
| 2,5-dimethoxy-4 -aminostilbene |
23435-31-6
|
High
|
| N-ethyl-N-formylhydrazine |
74920-78-8
|
High
|
| chlorthal-dimethyl |
1861-32-1
|
Medium High
|
| cyanazine |
21725-46-2
|
Medium High
|
| dapsone |
80-08-0
|
Medium High
|
| 2,4-dichlorophenoxyacetic acid and its salts and
esters |
94-75-7
|
Medium High
|
| dimethyl hydrogen phosphite |
868-85-9
|
Medium High
|
| furfural |
98-01-1
|
Medium High
|
| malonaldehyde and its salts |
24382-04-5
|
Medium High
|
| zearalenone |
17924-92-4
|
Medium High
|
| 2-biphenylamine (and strong acid salts) |
2185-92-4
|
Medium High
|
| bromoethane |
74-96-4
|
Medium High
|
| b -thioguanine deoxyriboside |
789-61-7
|
Medium High
|
| bis(tri-n-butyltin)oxide |
56-35-9
|
Medium
|
| dicofol |
115-32-2
|
Medium
|
| di(2-ethylhexyl)adipate |
103-23-1
|
Medium
|
| patulin |
149-29-1
|
Medium
|
| pentachloronitrobenzene |
82-68-8
|
Medium
|
| piperonyl sulfoxide |
120-62-7
|
Medium
|
CASRN = Chemical Abstracts Service Registration Number
Table 2. Final Candidate List as of June 12, 1998
| CHEMICAL |
CASRN
|
LEVEL OF EXPOSURE CONCERN
|
| p-chloronitrobenzene |
100-00-5
|
high
|
| estragole |
140-67-0
|
high
|
| trichloroacetic acid |
76-03-9
|
high
|
| bis(2-chloro-1-methylethyl)ether |
108-60-1
|
medium
|
| 2-aminofluorene |
153-78-6
|
low
|
| 4-amino-2-nitrophenol |
119-34-6
|
low
|
| acronycine |
7008-42-6
|
n.i.c.
|
| 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole |
3775-55-1
|
n.i.c.
|
| N-butyl-N-nitrosourea |
869-01-2
|
n.i.c.
|
| 2,5-dimethoxy-4¢ -aminostilbene |
23435-31-6
|
n.i.c.
|
| N-ethyl-N-formylhydrazine |
74920-78-8
|
n.i.c.
|
CASRN = Chemical Abstracts Service Registration Number
n.i.c. = No Identified Concern
Copies of the final data summaries and priority assignments for
these chemicals are available from the Proposition 65 Implementation
Office at the address and telephone number indicated below, or from
the Internet at the following address: www.oehha.ca.gov/prop65/pdf/dsb2rev.pdf
Download the set of final data summaries
and priority assignments as a 289 kb Adobe Acrobat PDF file.
Cynthia Oshita
Office of Environmental Health Hazard Assessment
1001 I Street, P.O. Box 4010
Sacramento, California 95812
Fax (916) 327-1097
(916) 445-6900
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print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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