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Proposition 65 - Prioritization Notices
Availability of Draft Data Summaries and Draft Priorities
For Chemicals With Respect to Their Potential to Cause Cancer: Request for Relevant Information
[10/17/03]

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The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA), as lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65), has developed a procedure for prioritizing chemicals for consideration under Proposition 65 by the "State's qualified experts." Two committees of the Science Advisory Board (SAB), known as the Carcinogen Identification Committee, and the Developmental and Reproductive Toxicant Identification Committee, serve as the State's qualified experts for rendering an opinion as to whether a chemical is known to the State to cause cancer, birth defects or other reproductive harm.

The procedure used by OEHHA to identify, prioritize and select candidate chemicals for evaluation by the SAB Committees is described in, "Procedure for Prioritizing Candidate Chemicals for Consideration Under Proposition 65 by the State's Qualified Experts," May 1997 and is available on the Internet at http://www.oehha.ca.gov. In accordance with this procedure, prioritized chemicals with a final priority of High Carcinogenicity Concern are assigned to the Candidate List, from which chemicals will be chosen for the preparation of hazard identification documents, and subsequent evaluation by the Carcinogen Identification Committee. All chemicals not assigned a final "high" level of carcinogenicity concern are assigned to Category II. Here draft priorities are identified as either "High" Carcinogenicity Concern, or "Not High" enough to merit placement on the Candidate List.

With this notice we are announcing the release of draft data summaries and draft priorities concerning the potential for the chemicals indicated below to cause cancer. This notice initiates a 60-day public comment period. These 50 chemicals were selected for prioritization as described in OEHHA's Notice to Interested Parties: Results of the Third Round Pilot Random Selection of the Chemicals Eligible for Prioritization For Consideration of Carcinogenicity Evaluation, published in the California Regulatory Notice Register (Register 01, No. 45-Z) on November 9, 2001. The chemicals and their draft priorities are as follows:

Name of Chemical
CAS No.
On Candidate List due to
HIGH CARCINOGENICITY CONCERN
4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene sulfonamide (sulfamethazine)
57-68-1
2-Chloro-1,1,1-trifluoroethane
(HCFC-133a)
75-88-7
Ciprofibrate
52214-84-3
Diallate
2303-16-4
Diftalone
21626-89-1
3,6-Dinitrobenzo[a]pyrene
128714-76-1
1,2-Epoxybutane
106-88-7
4-Hydroxybenzenediazonium and its salts
19089-85-1
Methimazole
60-56-0
4-Methylbenzenediazonium and its salts
57573-52-1
Molybdenum trioxide
1313-27-5
4-Nitrotoluene (p-nitrotoluene)
99-99-0
Nucleoside analogues, specifically:3'-Azido-3'-deoxythymidine (AZT, zidovudine)*
2'-,3'-Dideoxycytidine (ddC, zalcitabine)
Stavudine (d4T)
Trifluridine
30516-87-1
7481-89-2
3056-17-5
70-00-8
Propoxur (Baygon)
114-26-1
Titanium dioxide
13463-67-7
1,2,4-Trichlorobenzene
120-82-1
Verapamil
52-53-9

* AZT is also being considered separately under the authoritative bodies listing mechanism

Name of Chemical
CAS No
Category II (Not HIGH CARCINOGENICITY CONCERN)
Acephate
30560-19-1
Acetoxymethylphenylnitrosamine
81943-37-5
trans-Anethole
4180-23-8
Aspartame
22839-47-0
1-Benzoyl-2,6-dimethyl-4-nitrosopiperazine
61034-40-0
Chloroacetic acid
79-11-8
Chloromethane (methyl chloride)
74-87-3
Cholestyramine
11041-12-6
Clofentizine
74115-24-5
Cycloate
1134-23-2
3,4-Dihydrocoumarin
119-84-6
Dimethipin (Harvade)
55290-64-7
Flutamide
13311-84-7
Indolidan
100643-96-7
Isomazole and isomazole hydrochloride
86315-52-8;
87359-33-9
Isoniazid
54-85-3
Levobunolol and its salts
47141-42-4
Mecoprop and its salts
7085-19-0
Methyl methacrylate
80-62-6
Nicotine
54-11-5
3-Nitrofluoranthene
892-21-7
Orlistat
96829-58-2
Oxyfluorfen (Goal)
42874-03-3
Pyrimethamine (Daraprim)
58-14-0
Mineral fibers, manmade: now referred to as Synthetic vitreous fibers
Rockwool (stonewool)
Slagwool
Continuous glass filaments
---
Tralkoxydim
87820-88-0
Triethanolamine
102-71-6
Triflusulfuron-methyl
126535-15-7
Vitamin K (by injection in neonates)
12001-79-5
INADEQUATE DATA to establish level of concern
Pimozide
2062-78-4
POSTPONED  
Chromium picolinate (awaiting completion of NTP Bioassay)
14639-25-9
Fusarium moniliforme (Fusarium verticilliodes), toxins derived from (candidate for administrative listing)
---
Sodium nitrite (review being completed)
7632-00-0

OEHHA also announces that a public workshop to receive external scientific peer review and public comments on the draft data summaries and draft priority assignments for these chemicals will be held on Wednesday, November 19, 2003. The workshop will commence at 10:00 a.m. in Room 11, Second Floor, Elihu Harris State Building, 1515 Clay Street, Oakland, California, and will last until all business has been conducted or until 5:00 p.m.

OEHHA is committed to public participation and external scientific peer review in its implementation of Proposition 65, and welcomes public input. The draft data summaries and draft priority assignments for these chemicals are available from the Proposition 65 Implementation
Office at the address and telephone number indicated below, or from the Internet at the following address: http://www.oehha.ca.gov.

Written comments may be submitted in triplicate to:

Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
Street Address: 1001 I Street
Sacramento, California 95814
Mailing Address: P.O. Box 4010
Sacramento, California 95812-4010
Fax No.: (916) 323-8803
Telephone: (916) 445-6900

In order to be considered, comments must be postmarked (if sent by mail) or received at OEHHA (if delivered in person or sent by FAX) by 5 p.m. Tuesday, December 16, 2003.

Follow this link to download a copy of this notice.

Follow this link to download a copy of the data summaries.


You will need the free program Adobe Acrobat Reader to view or print PDF files Go to the Adobe web site

For questions regarding Proposition 65, please contact the Cynthia Oshita in the Proposition 65 Implementation Program

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