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The California Environmental Protection Agency's Office of Environmental
Health Hazard Assessment (OEHHA), as lead agency for the implementation
of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition
65), has developed a procedure for prioritizing chemicals for consideration
under Proposition 65 by the "State's qualified experts."
Two committees of the Science Advisory Board (SAB), known as the
Carcinogen Identification Committee, and the Developmental and Reproductive
Toxicant Identification Committee, serve as the State's qualified
experts for rendering an opinion as to whether a chemical is known
to the State to cause cancer, birth defects or other reproductive
harm.
The procedure used by OEHHA to identify, prioritize and select
candidate chemicals for evaluation by the SAB Committees is described
in, "Procedure
for Prioritizing Candidate Chemicals for Consideration Under Proposition
65 by the State's Qualified Experts," May 1997 and is available
on the Internet at http://www.oehha.ca.gov. In accordance with this
procedure, prioritized chemicals with a final priority of High Carcinogenicity
Concern are assigned to the Candidate List, from which chemicals
will be chosen for the preparation of hazard identification documents,
and subsequent evaluation by the Carcinogen Identification Committee.
All chemicals not assigned a final "high" level of carcinogenicity
concern are assigned to Category II. Here draft priorities are identified
as either "High" Carcinogenicity Concern, or "Not
High" enough to merit placement on the Candidate List.
With this notice we are announcing the release of draft data summaries
and draft priorities concerning the potential for the chemicals
indicated below to cause cancer. This notice initiates a 60-day
public comment period. These 50 chemicals were selected for prioritization
as described in OEHHA's Notice to Interested Parties: Results of
the Third Round Pilot Random Selection of the Chemicals Eligible
for Prioritization For Consideration of Carcinogenicity Evaluation,
published in the California Regulatory Notice Register (Register
01, No. 45-Z) on November
9, 2001. The chemicals and their draft priorities are as follows:
| Name of Chemical |
CAS No.
|
On Candidate List due to
HIGH CARCINOGENICITY CONCERN |
| 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene
sulfonamide (sulfamethazine) |
57-68-1
|
2-Chloro-1,1,1-trifluoroethane
(HCFC-133a) |
75-88-7
|
| Ciprofibrate |
52214-84-3
|
| Diallate |
2303-16-4
|
| Diftalone |
21626-89-1
|
| 3,6-Dinitrobenzo[a]pyrene |
128714-76-1
|
| 1,2-Epoxybutane |
106-88-7
|
| 4-Hydroxybenzenediazonium and its salts |
19089-85-1
|
| Methimazole |
60-56-0
|
| 4-Methylbenzenediazonium and its salts |
57573-52-1
|
| Molybdenum trioxide |
1313-27-5
|
| 4-Nitrotoluene (p-nitrotoluene) |
99-99-0
|
Nucleoside analogues, specifically:3'-Azido-3'-deoxythymidine
(AZT, zidovudine)*
2'-,3'-Dideoxycytidine (ddC, zalcitabine)
Stavudine (d4T)
Trifluridine |
30516-87-1
7481-89-2
3056-17-5
70-00-8
|
| Propoxur (Baygon) |
114-26-1
|
| Titanium dioxide |
13463-67-7
|
| 1,2,4-Trichlorobenzene |
120-82-1
|
| Verapamil |
52-53-9
|
* AZT is also being considered separately under the authoritative
bodies listing mechanism
| Name of Chemical |
CAS No
|
| Category II (Not HIGH CARCINOGENICITY CONCERN) |
| Acephate |
30560-19-1
|
| Acetoxymethylphenylnitrosamine |
81943-37-5
|
| trans-Anethole |
4180-23-8
|
| Aspartame |
22839-47-0
|
| 1-Benzoyl-2,6-dimethyl-4-nitrosopiperazine |
61034-40-0
|
| Chloroacetic acid |
79-11-8
|
| Chloromethane (methyl chloride) |
74-87-3
|
| Cholestyramine |
11041-12-6
|
| Clofentizine |
74115-24-5
|
| Cycloate |
1134-23-2
|
| 3,4-Dihydrocoumarin |
119-84-6
|
| Dimethipin (Harvade) |
55290-64-7
|
| Flutamide |
13311-84-7
|
| Indolidan |
100643-96-7
|
| Isomazole and isomazole hydrochloride |
86315-52-8;
87359-33-9
|
| Isoniazid |
54-85-3
|
| Levobunolol and its salts |
47141-42-4
|
| Mecoprop and its salts |
7085-19-0
|
| Methyl methacrylate |
80-62-6
|
| Nicotine |
54-11-5
|
| 3-Nitrofluoranthene |
892-21-7
|
| Orlistat |
96829-58-2
|
| Oxyfluorfen (Goal) |
42874-03-3
|
| Pyrimethamine (Daraprim) |
58-14-0
|
Mineral fibers, manmade: now referred to as Synthetic
vitreous fibers
Rockwool (stonewool)
Slagwool
Continuous glass filaments
|
---
|
| Tralkoxydim |
87820-88-0
|
| Triethanolamine |
102-71-6
|
| Triflusulfuron-methyl |
126535-15-7
|
| Vitamin K (by injection in neonates) |
12001-79-5
|
| INADEQUATE DATA to establish level of concern |
| Pimozide |
2062-78-4
|
| POSTPONED |
|
| Chromium picolinate (awaiting completion of NTP
Bioassay) |
14639-25-9
|
| Fusarium moniliforme (Fusarium verticilliodes),
toxins derived from (candidate for administrative listing) |
---
|
| Sodium nitrite (review being completed) |
7632-00-0
|
OEHHA also announces that a public workshop to receive external
scientific peer review and public comments on the draft data summaries
and draft priority assignments for these chemicals will be held
on Wednesday, November 19, 2003. The workshop will commence at 10:00
a.m. in Room 11, Second Floor, Elihu Harris State Building, 1515
Clay Street, Oakland, California, and will last until all business
has been conducted or until 5:00 p.m.
OEHHA is committed to public participation and external scientific
peer review in its implementation of Proposition 65, and welcomes
public input. The draft data summaries and draft priority assignments
for these chemicals are available from the Proposition 65 Implementation
Office at the address and telephone number indicated below, or from
the Internet at the following address: http://www.oehha.ca.gov.
Written comments may be submitted in triplicate to:
Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
Street Address: 1001 I Street
Sacramento, California 95814
Mailing Address: P.O. Box 4010
Sacramento, California 95812-4010
Fax No.: (916) 323-8803
Telephone: (916) 445-6900
In order to be considered, comments must be postmarked (if sent
by mail) or received at OEHHA (if delivered in person or sent by
FAX) by 5 p.m. Tuesday, December 16, 2003.
Follow
this link to download a copy of this notice.
Follow this link
to download a copy of the data summaries.
You will need the free program Adobe Acrobat Reader to view or
print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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