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Proposition 65 - Prioritization Notices

Results of the Third Round Pilot Random Selection of the Chemicals Eligible for Prioritization for Consideration of Carcinogenicity Evaluation
[11/09/01]

Table 1: Candidates for Random Selection Third Round


No.

Chemical Name

CAS
Number

Remarks

1.        

Acephate

30560-19-1

Pesticide - contact and systemic insecticide

2.        

Acetoxymethylphenyl-nitrosamine*

81943-37-5

Used for research on carcinogenesis

3.        

Allyl isothiocyanate*

57-06-7

Dog and cat repellent; flavoring

4.        

4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene sulfonamide (sulfamethazine)

57-68-1

Drug - antibacterial

5.        

3-Amino-4-ethoxyacetanilide*

17026-81-2

Intermediate for synthesis of dyes

6.        

Androstenedione

63-05-8

Dietary supplement - body building

7.        

trans-Anethole

4180-23-8

Food additive - anise flavoring; fragrance; naturally occurring essential oil

8.        

o-Anisidine-based dyes

------

Industrial chemicals - used to dye various types of materials

9.        

Anthanthrene*

191-26-4

Component of fossil fuels; product of incomplete combustion

10.    

Aspartame

22839-47-0

Food additive - sweetening agent

11.    

Atrazine*

1912-24-9

Pesticide - herbicide

12.    

Azafenidin

68049-83-2

Pesticide - preemergence herbicide used on crop and non-crop areas.

13.    

1-Benzoyl-2,6-dimethyl-4-nitrosopiperazine*

61034-40-0

Used for research on carcinogenesis

14.    

C.I. acid orange 3*

6373-74-6

Dye for nylon, wool, other materials

15.    

C.I. vat yellow 4*

128-66-5

Dye for cotton, silk, wool, paper

16.    

Carbamazepine*

298-46-4

Prescription drug used for treatment of epilepsy and trigeminal neuralgia

17.    

Chloroacetic acid

79-11-8

Chemical intermediate; pesticide - herbicide, preservative

18.    

2-Chloroalkyl ethers

----------

Industrial chemicals - solvents, lead scavenging; chemical intermediate; possible byproducts of water chlorination

19.    

Chloromethane (methyl chloride)*

74-87-3

Extensively used for silicone rubber synthesis

20.    

2-Chloro-1,1,1-trifluoroethane

75-88-7

Intermediate in halothane production; halothane used as anesthetic in CA

21.    

Cholestyramine

11041-12-6

Drug - antihyperlipoproteinemic

22.    

Chromium picolinate*

14639-25-9

Nutritional supplement

23.    

Ciprofibrate

52214-84-3

Drug - antihyperlipoproteinemic

24.    

Citral*

5392405

Chemical intermediate (e.g., in synthesis of vitamin A); flavoring and perfuming agent

25.    

Clofentizine

74115-24-5

Pesticide- miticide

26.    

trans-Crotonaldehyde*

123-73-9

Chemical intermediate in the manufacture of a variety of chemicals; solvent; fuel-gas warning agent; alcohol denaturant; leather tanning agent; used in locating breaks and leaks in pipes.

27.    

Cycloate

1134-23-2

Pesticide - herbicide

28.    

Dantrolene sodium

14663-23-1

Drug - used to control manifestations of clinical spasticity

29.    

D&C Yellow No. 11 (C.I. solvent yellow 33)*

8003-22-3

Pigment and dye

30.    

Diallate*

2303-16-4

Pesticide - selective herbicide

31.    

Diftalone*

21626-89-1

Drug - anti-inflammatory

32.    

3,4-Dihydrocoumarin

119-84-6

Food additive - flavoring agent in beverages and gelatins

33.    

Dihydropyridine calcium channel blockers, including amlodipine, felodipine, isradipine, nicardipine and nifedipine

88150-42-9; 72509-76-3; 75695-93-1; 55985-32-5; 21829-25-4

Drugs - antihypertensive agents

34.    

Dimethipin

55290-64-7

Industrial chemical - plant growth regulator

35.    

3,6-Dinitrobenzo[a]pyrene

128714-76-1

Air pollutant - particulate air contaminant

36.    

Elemicin

487-11-6

Naturally occurring compound, found in nutmeg

37.    

1,2-Epoxybutane

106-88-7

Industrial chemical - stabilizer for chlorinated hydrocarbon solvents

38.    

FD&C Green No. 1 (guinea green B)*

4680-78-8

Dye for wool, silk, leather, paper; cosmetic pigment

39.    

FD&C Green No. 2 (Light Green FS)

5141-20-8

Industrial chemical - dye used to color fabric and wood

40.    

Fipronil*

120068-37-3

Pesticide - insecticide

41.    

Flutamide

13311-84-7

Drug - antineoplastic

42.    

Fomesafen

72128-02-0

Pesticide - herbicide used on soy beans

43.    

Fusarium moniliforme, toxins derived from

------

Mold found on corn and other grains

44.    

Haloxyfop-methyl

69806-40-2

Pesticide - herbicide used on postemergent grass

45.    

Hydroxybenzene-diazonium sulfate

---------

Naturally occurring chemical - found in mushrooms

46.    

Imidacloprid*

105827-78-9

Pesticide - insecticide

47.    

Indolidan

100643-96-7

Drug - heart medication

48.    

Isomazole and its hydrochloride

87359-33-9; 86315-52-8

Drug - heart medication

49.    

Isoniazid

54-85-3

Drug - antitubercular agent, antibacterial; chemical intermediate -- used to manufacture other antitubercular agents

50.    

Levobunolol (and salt)

47141-42-4 (27912-14-4)

Drug - antiglaucoma agent

51.    

Mecoprop & its salts (including methoxone sodium)*

7085-19-0

Pesticide - herbicide

52.    

Methacrylonitrile

126-98-7

Industrial chemical - used in production of plastic elastomers and coatings

53.    

Methidathion

950-37-8

Pesticide - non-systemic insecticide

54.    

Methimazole

60-56-0

Drug - antihyperthyroid

55.    

Methoxychlor*

72-43-5

Pesticide - insecticide; ectoparasiticide in veterinary medicine

56.    

4-Methoxy-2-methylbenzeneamine (m-cresidine)*

102-50-1

Industrial chemical dye intermediate

57.    

4-(Methyl)benzene-diazonium sulfate*

32066-79-8

Used for research on carcinogenesis

58.    

Methyl methacrylate*

80-62-6

Widely used for polymer synthesis

59.    

s-Metolachlor

87391-12-9

Pesticide herbicide

60.    

MGK-264

113-48-4

Pesticide additive - synergist for pyrethroid pesticides used in aerosol sprays for household and veterinary use

61.    

Mineral fibers, man-made

------

Industrial chemicals - insulation materials

62.    

Molybdenum trioxide*

1313-27-5

Used in alloys and as catalyst

63.    

Nabam

142-59-6

Pesticide - systemic fungicide; chemical intermediate for fungicides

64.    

1,5-Naphthalenediamine*

2243-62-1

Chemical intermediate

65.    

Nicotine

54-11-5

Tobacco constituent; drug - smoking cessation aid; pesticide - insecticide; tanning

66.    

Nithiazide*

139-94-6

Antiprotozoan drug in poultry

67.    

3-Nitrofluoranthene

892-21-7

Air pollutant - component of air particulate matter

68.    

4-(5-Nitro-2-furyl)thiazole*

53757-28-1

Used for research on carcinogenesis

69.    

N-Nitrosoazetidine*

15216-10-1

Component of tobacco smoke

70.    

4-Nitrotoluene (p-nitrotoluene)

99-99-0

Industrial chemical - high production volume

71.    

Nucleoside analogues, including 2',3'-dideoxycytidine (ddC), ribavirin, trifluridine, vidarabine, and zidovudine (AZT)*

7481-89-2;

36791-04-5; 70-00-8;

5536-17-4;

30516-87-1

Drugs - anti-viral, -fungal, -psoriasis, and chemotherapeutic

72.    

Orlistat

96829-58-2

Drug - weight loss

73.    

Oryzalin*

19044-88-3

Pesticide - herbicide

74.    

Oxyfluorfen*

42874-03-3

Pesticide - herbicide

75.    

Pendimethalin*

40487-42-1

Pesticide - selective herbicide

76.    

Permethrin*

52645-53-1

Pesticide - insecticide, acaricide, and nematocide

77.    

Phomopsin A*

64925-80-0

Mycotoxin produced by certain fungi

78.    

Pimozide

2062-78-4

Drug - antipsychotic

79.    

Piperonyl butoxide

51-03-6

Pesticide - synergist, insecticide formulations

80.    

Propoxur*

114-26-1

Pesticide - insecticide

81.    

Pyrimethamine (daraprim)

58-14-0

Drug - treatment of acute malaria, toxoplamosis, chemoprophylaxis of malaria; veterinary drug

82.    

Simazine*

122-34-9

Pesticide - herbicide

83.    

Sodium nitrite*

7632-00-0

Food preservative

84.    

Sulfur trioxide

7446-11-9

Industrial chemical - sulfuric acid manufacture

85.    

Terbinafine hydrochloride cream

78628-80-5

Drug - prescription, antifungal

86.    

Terbutaline

23031-25-6

Drug - prescription, asthma medication

87.    

Tetrahydrofuran

109-99-9

Industrial chemical - solvent; chemical intermediate

88.    

Titanium dioxide

13463-67-7

Industrial chemical - pigment

89.    

Tralkoxydim

87820-88-0

Pesticide - herbicide

90.    

Triadimefon

43121-43-3

Pesticide - fungicide

91.    

Triamterene

396-01-0

Drug - diuretic that conserves potassium

92.    

1,2,4-Trichlorobenzene

120-82-1

Industrial chemical - high production volume, solvent; chemical intermediate

93.    

1,1,1-Trichloroethane

71-55-6

Industrial chemical - solvent, cleaning agent

94.    

Triethanolamine

102-71-6

Industrial chemical - surfactant, gas purification, textiles; pesticide

95.    

Triflusulfuron-methyl

126535-15-7

Pesticide - herbicide

96.    

2,4,6-Trinitrotoluene

118-96-7

Industrial chemical - used in explosives and some consumer products

97.    

Undecane

1120-21-4

Industrial chemical - component of naphtha and gasoline; chemical intermediate - used to produce chlorinated paraffins

98.    

Verapamil

52-53-9

Drug - hypertension (calcium channel blocker)

99.    

Vitamin K (by injection in neonates)

12001-79-5

Drug - prescription/therapeutic; vitamin essential for normal blood clotting

100.    

Ziram*

137-30-4

Accelerator for rubber production; fungicide on food crops; pesticide (snail control)

 


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