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The Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition
65) provides two mechanisms for administratively listing chemicals
which are known to the State to cause reproductive toxicity or cancer
(Health and Safety Code Section 25249.8(b)). One such mechanism
involves the listing of chemicals that a body, considered to be
authoritative by the state's qualified experts, formally identifies
as causing cancer or reproductive toxicity. As the lead agency for
the implementation of Proposition 65, the Office of Environmental
Health Hazard Assessment (OEHHA) of the California Environmental
Protection Agency reviews candidates for listing pursuant to this
administrative mechanism as provided in Health and Safety Code Section
25249.8(b) and Title 22, California Code of Regulations, Section
12306 (22 CCR 12306).
The U.S. Environmental Protection Agency (U.S. EPA), an authoritative
body for purposes of Proposition 65 (22 CCR 12306(l)), identifies
chemicals as causing developmental or reproductive toxicity in implementing
its Toxic Release Inventory (TRI) program (i.e., Section 313 of
the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA)).
On this basis the U.S. EPA, in 1994, added a number of chemicals
to the TRI list and published its inclusions to the list in the
Federal Register (59:1788-1859, 1994 and 59:61432-61485, 1994).
OEHHA has reviewed the bases for these TRI chemical additions in
the context of the regulatory criteria governing Proposition 65
listing via the authoritative bodies mechanism (22 CCR 12306).
OEHHA determined for several TRI chemicals that the 22 CCR 12306
regulatory criteria were met and have placed these chemicals on
the Proposition 65 list of chemicals known to cause reproductive
toxicity. OEHHA continues the process of considering the remaining
chemicals for placement on the Proposition 65 list of chemicals.
Metribuzin is one of these remaining TRI chemicals. There is significant
ambiguity in the record regarding how U.S. EPA characterizes the
reproductive toxicity of metribuzin. Therefore, metribuzin is no
longer under consideration for administrative listing. Metribuzin
will be referred to the Developmental and Reproductive Toxicant
(DART) Identification Committee. At a future meeting, the DART Identification
Committee will opine whether "the chemical has been clearly
shown through scientifically valid testing according to generally
accepted principles" to cause reproductive toxicity.
TRI chemical being referred to the DART Identification Committee
for its consideration under Proposition 65
| Chemical |
CAS No |
| Metribuzin |
21087-64-9 |
A document providing more detail on the basis for this determination
can be obtained from OEHHA's Proposition 65 Implementation Office
at the address and telephone number indicated below, or from the
OEHHA Home Page at: http://www.oehha.ca.gov/ . Questions regarding
this notice should be directed to:
Ms. Cynthia
Oshita
Office of Environmental Health Hazard Assessment
Post Office Box 4010
Sacramento, CA 95812-4010
Fax No.: (916) 327-1097
Telephone: (916) 445-6900
Follow this link
to download a copy of this notice.
Follow this link
to download a copy of the document providing more detail on the
basis for this determination.
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print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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