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The California Environmental Protection Agency’s Office of Environmental
Health Hazard Assessment (OEHHA) is the lead agency for the implementation
of the Safe Drinking Water and Toxic Enforcement Act of 1986
(Proposition 65; Health and Safety Code Section 25249.5 et seq.).
The Carcinogen Identification Committee of OEHHA’s Science Advisory
Board provides advice on the list of chemicals known to the State
to cause cancer, which pursuant to Proposition 65 must be updated
annually. The Committee serves as the State’s qualified experts
for rendering an opinion whether a chemical has been clearly shown
through scientifically valid testing according to generally accepted
principles to cause cancer.
OEHHA has developed a procedure for prioritizing candidate chemicals
for consideration under Proposition 65 by the State’s qualified
experts. The process is described in "Procedure
for Prioritizing Candidate Chemicals for Consideration Under Proposition
65 by the State’s Qualified Experts," May 1997, and is
available on the Internet at www.oehha.ca.gov.
On February 18, 1999, OEHHA released for public comment
draft priority assignments
and draft data summaries for 59 chemicals with respect to their
potential to cause cancer. OEHHA announced the final priority assignments
for 54 of these chemicals in a separate notice published elsewhere
in this issue of the California Regulatory Notice Register.
In accordance with OEHHA’s prioritization procedure, all chemicals
with final priority assignments of "high" carcinogenicity
concern are placed on the final Candidate List (Table 1). Chemicals
are then selected from the Candidate List for the development of
draft cancer hazard identification documents and subsequent consideration
for listing by the Carcinogen Identification Committee of OEHHA’s
Science Advisory Board. Consistent with OEHHA’s current (May 1997)
prioritization procedure, chemicals with the highest level of exposure
concern will be selected first from the Candidate List.
TABLE 1. Final Candidate List as of August 6, 1999
|
CHEMICAL
|
CAS No.
|
LEVEL OF EXPOSURE CONCERN
|
|
allyl isovalerate
|
2835-39-4
|
high
|
|
carboxymethylnitrosourea
|
60391-92-6
|
high
|
|
hexachlorobutadiene
|
87-68-3
|
high
|
|
4-methylquinoline
|
491-35-0
|
high
|
|
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone)
|
77439-76-0
|
high
|
|
pyrrolizidine alkaloids which are metabolized to dehydroretronecine
or dehydroheliotridine
|
---
|
high
|
|
sesamol
|
533-31-3
|
high
|
|
bleomycin
|
11056-06-7
|
medium
|
|
chrysoidine
|
532-82-1
|
medium
|
|
N,N'-diethylthiourea
|
105-55-5
|
medium
|
|
isophosphamide
|
3778-73-2
|
medium
|
|
6-nitrobenzimidazole
|
94-52-0
|
medium
|
|
petasitenine
|
60102-37-6
|
medium
|
|
1-butylhydrazine hydrochloride
|
56795-65-4
|
low
|
|
3,3'-dimethoxybenzidine-4,4'-diisocyanate
|
91-93-0
|
low
|
|
estradiol mustard
|
22966-79-6
|
low
|
|
pivalolactone
|
1955-45-9
|
low
|
|
2,4,6-trimethylaniline and its hydrochloride (aminomesitylene)
|
88-05-1
|
low
|
|
4-bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)-quinazoline
|
33372-39-3
|
n.i.c.
|
|
3-chloromethylpyridine hydrochloride
|
6959-48-4
|
n.i.c.
|
|
dimethyldiazene-1-oxide (methylazoxymethane / azoxymethane)
|
25843-45-2
|
n.i.c.
|
|
N'-ethyl-N-methyl-N-nitrosourea
|
72479-13-1
|
n.i.c.
|
|
N'-ethyl-N-nitrosobutylamine
|
4549-44-4
|
n.i.c.
|
|
4-ethylsulfonylnaphthalene-1-sulfonamide
|
842-00-2
|
n.i.c.
|
|
ICRF-159
|
21416-87-5
|
n.i.c.
|
|
3'-methyl-4-dimethylaminoazobenzene
|
55-80-1
|
n.i.c.
|
|
N-nitrosomethyl-N-heptylamine
|
16338-99-1
|
n.i.c.
|
|
N-nitroso-N-pentylurea (N-amyl-N-nitrosurea)
|
10589-74-9
|
n.i.c.
|
|
N-(2-methoxyethyl)-N-nitrosourea
|
108278-70-2
|
inadequate data
|
n.i.c. – No identified concern
At this time, OEHHA requests information relevant to the assessment
of the evidence of carcinogenicity on the following chemicals:
|
CHEMICAL
|
CAS No.
|
|
allyl isovalerate
|
2835-39-4
|
|
carboxymethylnitrosourea
|
60391-92-6
|
|
hexachlorobutadiene
|
87-68-3
|
|
4-methylquinoline
|
491-35-0
|
|
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone)
|
77439-76-0
|
|
pyrrolizidine alkaloids which are metabolized to dehydroretronecine
or dehydroheliotridine
|
---
|
|
sesamol
|
533-31-3
|
Interested parties or members of the public wishing to provide
information relevant to the assessment of these chemicals should
forward such information to the address given below. The publication
of this notice marks the start of a 60-day data call-in period.
This period ends on Tuesday, October 5, 1999. The information received
during this data call-in period will be reviewed and considered
by OEHHA as it develops the draft cancer hazard identification documents
on these compounds.
OEHHA welcomes public participation and public input as part of
these scientific assessments. If there is sufficient public interest
in a specific candidate chemical, a workshop or other public forum
will be held to encourage scientific dialogue prior to completion
of the draft hazard identification document.
Notification of the availability of the hazard identification documents
and of the time, date, location, and agenda of any workshops and
of the next meeting of the Carcinogen Identification Committee will
be provided in subsequent notices published in the California Regulatory
Notice Register and posted on OEHHA’s Home Page at www.oehha.ca.gov.
It is anticipated that the draft hazard identification documents
will be made available for a 60-day comment period prior to the
committee meetings at which these chemicals will be considered.
Relevant information on these chemicals should be sent in triplicate
by mail or fax to:
Cynthia Oshita
Office of Environmental Health Hazard Assessment
Post Office Box 4010
Sacramento, CA 95812-4010
Fax (916) 327-1097
Telephone (916) 445-6900
In order to be considered, the relevant information must be postmarked
(if sent by mail) or received at OEHHA (if delivered in person or
sent by FAX) by 5:00 PM on Tuesday, October 5, 1999.
Follow
this link to download this Notice in PDF format.
You will need the free program Adobe Acrobat Reader to view or
print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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