The California Environmental Protection Agency’s (Cal/EPA), Office of Environmental Health Hazard Assessment (OEHHA) convened a meeting of the Proposition 65 Developmental and Reproductive Toxicant Identification Committee (DARTIC) on October 21, 2010. The meeting was held at the Cal/EPA Headquarters Building in Sacramento, California.
The Committee:
The agenda of the meeting and meeting materials is available at http://www.oehha.ca.gov/prop65/public_meetings/DART100810.html
Below is a synopsis of the meeting.
Following a staff presentation, comments from the public and committee discussion, the DARTIC determined that MIC has been clearly shown to cause developmental toxicity and female reproductive toxicity. The chemical was added to the Proposition 65 chemical list as known to cause reproductive toxicity (developmental and female reproductive toxicity endpoints) effective November 12, 2010. The DARTIC did not find that MIC has been clearly shown to cause male reproductive toxicity.
Follow these links to the slide presentations made at the meeting by OEHHA staff:
Staff and the committee discussed the next data screen to apply in OEHHA’s prioritization of chemicals for possible DARTIC review. OEHHA suggested screening candidate chemicals first to identify chemicals that are known to occur in humans, then to screen that subset of candidate chemicals for those that have a substantial amount of relevant toxicological animal data. Such a screen would give OEHHA flexibility to use its resources more efficiently. The DARTIC indicated agreement and also advised that the previously-used epidemiologic data screen should be repeated at some point in the future. A complete discussion of OEHHA’s prioritization process can be found at this link: http://www.oehha.ca.gov/prop65/CRNR_notices/state_listing/pdf/finalPriordoc.pdf
Follow this link to the presentation made by OEHHA staff:
Following the staff presentation and committee discussion, the DARTIC advised that they preferred the following approaches:
Following the staff presentation and committee discussion, the DARTIC tabled the discussion of the American Chemistry Council’s petition for reconsideration of the National Toxicology Program as an authoritative body. Instead, the DARTIC requested that an informational presentation be made by OEHHA staff at the next committee meeting to educate the committee about the four listing mechanisms available under Proposition 65.
A copy of the meeting transcript is available here.
