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The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding propoxur (CAS No. 114-26-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of propoxur is effective August 11, 2006.

Propoxur (CAS No. 114-26-1) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (i.e., the U.S. Environmental Protection Agency (“U.S. EPA”), that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 22, Cal. Code of Regs., section 12306.

The reader is directed to the Notice of Intent to List propoxur (CAS No. 114-26-1) published in the November 25, 2005, issue of the California Regulatory Notice Register (Register 2005, No. 47-Z) for the documentation supporting OEHHA's determination that the criteria for administrative listing have been satisfied for this chemical. The listing of the chemical iprovalicarb , which was included in the November 25, 2005 Notice of Intent to List, is still under consideration and will be the subject of a future public notice. One public comment was received on the proposed listing of propoxur during the 30-day comment period that closed on January 9, 2006.

OEHHA analyses of dose-response data to establish the no significant risk level (NSRL) for propoxur (CAS No. 114-26-1) under Proposition 65 have not yet been conducted. The priority status for the development of such analyses will be announced in a future OEHHA Proposition 65 Status Report for Safe Harbor Levels , available at http://www.oehha.ca.gov/prop65.html .

OEHHA is also making correction to the listing of the chemical adriamycin (doxorubicin hydrochloride) (CAS No. 23214-92-8). Adriamycin (doxorubicin hydrochloride) was listed as a chemical known to cause cancer on July 1, 1987. It was also listed as known to cause developmental and male reproductive toxicity under the name of doxorubicin hydrochloride on January 29, 1999. Since it is the same chemical with the same CAS number but has two different names, the chemical will be correctly listed as doxorubicin hydrochloride (adriamycin) for the endpoints of cancer, developmental and male reproductive toxicity. The effective dates of the listing of the chemical under the three endpoints remain the same.

A complete, updated Proposition 65 list is published elsewhere in this issue of the California Regulatory Notice Register.

Cancer

Reproductive toxicity

Health and Safety Code section 25249.5 et seq.

Listing mechanism: AB – “authoritative bodies” mechanism (Title 22, Cal. Code of Regs. Section 12306).

Listing mechanism: SQE – “state's qualified experts” mechanism (22 Cal. Code of Regs Section 12305(b)(1).

Listing mechanism: FR – “formally required to be labeled or identified” mechanism (22 Cal. Code of Regs. Section 12902).

Follow this link to download a copy of this notice as a pdf file.

Download the August 11, 2006 list sorted alphabetically as a PDF file here.

If you would like to sort the list by CAS number or date, please download the August 11, 2006 list as a MS Excel spreadsheet here. You can then sort the list by date, CAS number or chemical name using MS Excel.

You can also download the list in Excel, hyphenated and with the associated Safe Harbor Levels here.

You will need the free program Adobe Acrobat Reader to view or print PDF files

For questions regarding Proposition 65, please contact the Cynthia Oshita in the Proposition 65 Implementation Program

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