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The Office of Environmental Health Hazard Assessment is making several corrections to the list of chemicals as known to the State of California to cause cancer or reproductive toxicity which was published on October 29, 1999 in the California Regulatory Notice Register, (Register 99, No. 44-Z).  The listing of the chemicals, 1,4-Butanediol dimethylsulfonate(Busulfan), CAS No. 55-58-1, which was listed as known to the State to cause developmental toxicity on January 1, 1989 and 1-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCN) (Lomustine), CAS No.13010-47-4, which was listed as known to the State to cause developmental toxicity on July 1, 1990 contain spelling errors.  The proper spelling of the two chemicals is shown in the table below.  On February 27, 1987, Diethylstilbestrol, CAS 56-53-1, was listed as a chemical known to the State to cause cancer and then on July 1, 1987, Diethylstilbestrol (DES), CAS 56-53-1, was listed as a chemical known to the State to cause developmental toxicity.  For clarity and consistency, the abbreviation (DES) will be included in the listing for both endpoints.  The chemical, Streptozotocin, CAS No. 18883-66-4, which was listed as known to the State to cause cancer on January 1, 1988, was later listed as known to the State to cause developmental toxicity, female reproductive toxicity and male reproductive toxicity on August 20, 1999; with the same CAS number but under a different listing name, streptozocin.  Streptozocin and streptozotocin are synonyms and for clarity and consistency, the listing of the chemical under all endpoints will make reference to both names. The chemical, Idarubicin hydrochloride was originally listed as known to the State to cause developmental toxicity and male reproductive toxicity on August 20, 1999 without a CAS number.  OEHHA has since determined its CAS number to be 57852-57-0.

Following is the correct listing of these chemicals. 

Chemicals Known to the State to Cause Cancer

Chemical	CAS No.	Date of Listing
Diethylstilbestrol (DES)	56-53-1	February 27, 1987
Streptozotocin (streptozocin)	18883-66-4	January 1, 1988

Chemicals Known to the State to Cause to Cause Reproductive Toxicity:

Chemical	CAS No.	Toxicological Endpoint	Date of Listing
1,4-Butanediol dimethanesulfonate (Busulfan)	55-58-1	developmental toxicity	January 1, 1989
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCN) (Lomustine)	13010-47-4	developmental toxicity	July 1, 1990
Idarubicin hydrochloride	57852-57-0	developmental toxicity male reproductive toxicity	August 20, 1999
Streptozocin (streptozotocin)	18883-66-4	developmental toxicity female reproductive toxicity male reproductive toxicity	August 20, 1999

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